B8YP89 · B8YP89_MOUSE
- ProteinParkin RBR E3 ubiquitin protein ligase
- GenePrkn
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids106 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score1/5
Publications for B8YP89
The PINK1/Parkin pathway of mitophagy exerts a protective effect during prion disease.
- CategoryFunction
- SourceMGI: 1355296
Ubiquitin Ligase Parkin Regulates the Stability of SARS-CoV-2 Main Protease and Suppresses Viral Replication.
- AnnotationUbiquitin Ligase Parkin Regulates the Stability of SARS-CoV-2 Main Protease and Suppresses Viral Replication.
- CategoryFunction
- SourceGeneRif: 50873
Parkin depletion prevents the age-related alterations in the FGF21 system and the decline in white adipose tissue thermogenic function in mice.
- AnnotationParkin depletion prevents the age-related alterations in the FGF21 system and the decline in white adipose tissue thermogenic function in mice.
- CategoryFunction
C-type natriuretic peptide improves maternally aged oocytes quality by inhibiting excessive PINK1/Parkin-mediated mitophagy.
- AnnotationC-type natriuretic peptide improves maternally aged oocytes quality by inhibiting excessive PINK1/Parkin-mediated mitophagy.
- CategoryFunction
- SourceGeneRif: 50873
PA2G4/EBP1 ubiquitination by PRKN/PARKIN promotes mitophagy protecting neuron death in cerebral ischemia.
- AnnotationPA2G4/EBP1 ubiquitination by PRKN/PARKIN promotes mitophagy protecting neuron death in cerebral ischemia.
- CategoriesFunction, Sequences
- SourceGeneRif: 50873
Critical roles of parkin and PINK1 in coxsackievirus B3-induced viral myocarditis.
- AnnotationCritical roles of parkin and PINK1 in coxsackievirus B3-induced viral myocarditis.
- CategoryFunction
- SourceGeneRif: 50873
Effects of Parkin on the Mitochondrial Genome in the Heart and Brain of Mitochondrial Mutator Mice.
- AnnotationEffects of Parkin on the Mitochondrial Genome in the Heart and Brain of Mitochondrial Mutator Mice.
- CategoryFunction
- SourceGeneRif: 50873
HYPERBILIRUBINEMIA AGGRAVATES RENAL ISCHEMIA REPERFUSION INJURY BY EXACERBATING PINK1-PARKIN-MEDIATED MITOPHAGY.
- AnnotationHYPERBILIRUBINEMIA AGGRAVATES RENAL ISCHEMIA REPERFUSION INJURY BY EXACERBATING PINK1-PARKIN-MEDIATED MITOPHAGY.
- CategoryFunction
- SourceGeneRif: 50873
Alpha-synuclein-associated changes in PINK1-PRKN-mediated mitophagy are disease context dependent.
- AnnotationAlpha-synuclein-associated changes in PINK1-PRKN-mediated mitophagy are disease context dependent.
- CategoryFunction
- SourceGeneRif: 50873
Reduced mitophagy is an early feature of NAFLD and liver-specific PARKIN knockout hastens the onset of steatosis, inflammation and fibrosis.
- AnnotationReduced mitophagy is an early feature of NAFLD and liver-specific PARKIN knockout hastens the onset of steatosis inflammation and fibrosis.
- CategoriesFunction, Phenotypes & Variants
Parkin regulates microglial NLRP3 and represses neurodegeneration in Parkinson's disease.
- AnnotationParkin regulates microglial NLRP3 and represses neurodegeneration in Parkinson's disease.
- CategoriesFunction, Phenotypes & Variants
- SourceGeneRif: 50873
Dysfunction in parkin aggravates inflammatory bone erosion by reinforcing osteoclast activity.
- CategoryFunction
- SourceMGI: 1355296
RhoA rescues cardiac senescence by regulating Parkin-mediated mitophagy.
- AnnotationRhoA rescues cardiac senescence by regulating Parkin-mediated mitophagy.
- CategoryFunction
Mitochondrial fragmentation and donut formation enhance mitochondrial secretion to promote osteogenesis.
- CategoriesFunction, Subcellular Location
- SourceMGI: 1355296
PINK1/Parkin-mediated mitophagy inhibits osteoblast apoptosis induced by advanced oxidation protein products.
- AnnotationPINK1/Parkin-mediated mitophagy inhibits osteoblast apoptosis induced by advanced oxidation protein products.
- CategoryFunction
- SourceGeneRif: 50873
Parkin coregulates glutathione metabolism in adult mammalian brain.
- AnnotationParkin coregulates glutathione metabolism in adult mammalian brain.
- CategoryFunction
Site-specific ubiquitination of VDAC1 restricts its oligomerization and mitochondrial DNA release in liver fibrosis.
- CategoriesFunction, PTM / Processing
- SourceMGI: 1355296
Loss of parkin causes endoplasmic reticulum calcium dyshomeostasis by upregulation of reticulocalbin 1.
- AnnotationLoss of parkin causes endoplasmic reticulum calcium dyshomeostasis by upregulation of reticulocalbin 1.
- CategoryFunction
- SourceGeneRif: 50873
A role for BCL2L13 and autophagy in germline purifying selection of mtDNA.
- CategoryFunction
- SourceMGI: 1355296