LTF mRNA was undetectable in the mouse brain even after ICH. Unlike mRNA LTF protein increased in ICH-affected hemispheres by 6 hours peaked at 24 to 72 hours and remained elevated for at least a week after ICH. At the single cell level LTF was detected in PMNs in the hematoma-affected brain at all time points after ICH. We also found elevated LTF in the plasma after ICH.
administration of lactoferrin led to autopotentiated increased expression of the LTF gene. The decreased lactoferrin mRNA levels in association with obesity and diabetes were replicated in mice adipose tissue
The up-regulation of lactorferrin in the brains of the transgenic mouse model of Alzheimer's disease provides evidence of an important role for lactoferrin in alzheimer disease-affected brain tissues
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