B8XXQ3 · B8XXQ3_HUMAN
- ProteinPatatin-like phospholipase 1
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids532 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score2/5
Function
Features
Showing features for active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 53 | Nucleophile | ||||
Sequence: S | ||||||
Active site | 172 | Proton acceptor | ||||
Sequence: D |
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | lipid droplet | |
Cellular Component | membrane | |
Molecular Function | triglyceride lipase activity | |
Biological Process | lipid homeostasis | |
Biological Process | triglyceride catabolic process |
Keywords
- Molecular function
- Biological process
Names & Taxonomy
Protein names
- Submitted names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionB8XXQ3
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Expression
Gene expression databases
Structure
Family & Domains
Features
Showing features for domain, motif, region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 16-185 | PNPLA | ||||
Sequence: ISFSGSGFLSFYQAGAVDALRDLAPRMLETAHRFAGTSAGAVIAALAICGIEMDEYLRVLNVGVAEVKKSFLGPLSPSCKMVQMMRQFLYRVLPEDSYKVTTGKLHVSLTRLTDGENVVVSEFTSKEELIEALYCSCFVPVYCGLIPPTYRGVRYIDGGFTGMQPCAFWT | ||||||
Motif | 51-55 | GXSXG | ||||
Sequence: GTSAG | ||||||
Motif | 172-174 | DGA/G | ||||
Sequence: DGG | ||||||
Region | 290-457 | Disordered | ||||
Sequence: PERSQPSLRARQASLEGATQPHKEWVPKGDGRGSHGPPVSQPVQTLEFTCESPVSAPVSPLEQPPAQPLASSTPLSLSGMPPVSFPAVHKPPSSTPGSSLPTPPPGLSPLSPQQQVQPSGSPARSLHSQAPTSPRPSLGPSTVGAPQTLPRSSLSAFPAQPPVEELGQ | ||||||
Compositional bias | 327-341 | Polar residues | ||||
Sequence: PVSQPVQTLEFTCES | ||||||
Compositional bias | 354-368 | Polar residues | ||||
Sequence: PAQPLASSTPLSLSG | ||||||
Compositional bias | 385-400 | Pro residues | ||||
Sequence: PGSSLPTPPPGLSPLS | ||||||
Compositional bias | 401-444 | Polar residues | ||||
Sequence: PQQQVQPSGSPARSLHSQAPTSPRPSLGPSTVGAPQTLPRSSLS | ||||||
Region | 489-532 | Disordered | ||||
Sequence: VTESPAEDSNWVNKVFKKNKQKTSGTRKGFPRHSGSKKPSSKVQ | ||||||
Compositional bias | 508-523 | Basic residues | ||||
Sequence: KQKTSGTRKGFPRHSG |
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length532
- Mass (Da)57,875
- Last updated2009-03-03 v1
- Checksum175852A0FFABE035
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 327-341 | Polar residues | ||||
Sequence: PVSQPVQTLEFTCES | ||||||
Compositional bias | 354-368 | Polar residues | ||||
Sequence: PAQPLASSTPLSLSG | ||||||
Compositional bias | 385-400 | Pro residues | ||||
Sequence: PGSSLPTPPPGLSPLS | ||||||
Compositional bias | 401-444 | Polar residues | ||||
Sequence: PQQQVQPSGSPARSLHSQAPTSPRPSLGPSTVGAPQTLPRSSLS | ||||||
Compositional bias | 508-523 | Basic residues | ||||
Sequence: KQKTSGTRKGFPRHSG |
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
FJ457781 EMBL· GenBank· DDBJ | ACJ70710.1 EMBL· GenBank· DDBJ | mRNA |