B8XVQ1 · B8XVQ1_MAIZE

  • Protein
    Cysteine protease
  • Gene
    Atg4b
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Evidence at transcript level
  • Annotation score
    2/5

Function

function

Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins. The protease activity is required for proteolytic activation of ATG8 family proteins: cleaves the C-terminal amino acid of ATG8 proteins to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. In addition to the protease activity, also mediates delipidation of PE-conjugated ATG8 proteins.

Catalytic activity

GO annotations

all annotationsall molecular functionnucleotide bindingmolecular_functionnucleic acid bindingdna bindingchromatin bindingdna-binding transcription factor activityrna bindingcytoskeletal motor activitycatalytic activitynuclease activitysignaling receptor bindingstructural molecule activitytransporter activitybindingprotein bindingtranslation factor activity, rna bindinglipid bindingkinase activitytransferase activityhydrolase activityoxygen bindingenzyme regulator activitycarbohydrate bindingsignaling receptor activitytranslation regulator activitytranscription regulator activityother molecular functionall biological processcarbohydrate metabolic processgeneration of precursor metabolites and energynucleobase-containing compound metabolic processdna metabolic processtranslationlipid metabolic processtransportresponse to stresscell cyclecell communicationsignal transductioncell-cell signalingmulticellular organism developmentcircadian rhythmbiological_processmetabolic processcatabolic processbiosynthetic processresponse to light stimulusresponse to external stimulustropismresponse to biotic stimulusresponse to abiotic stimulusresponse to endogenous stimulusembryo developmentpost-embryonic developmentfruit ripeningabscissionpollinationflower developmentcellular processprogrammed cell deathphotosynthesiscellular component organizationcell growthprotein metabolic processcellular homeostasissecondary metabolic processreproductive processcell differentiationprotein modification processgrowthepigenetic regulation of gene expressionresponse to chemicalanatomical structure developmentregulation of molecular functionother biological processall cellular componentcellular_componentextracellular regioncell wallintracellular anatomical structurenucleusnuclear envelopenucleoplasmnucleoluscytoplasmmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuscytosolribosomecytoskeletonplasma membranechloroplastplastidthylakoidmembraneexternal encapsulating structureother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytoplasm
Molecular Functioncysteine-type peptidase activity
Molecular Functionprotein-phosphatidylethanolamide deconjugating activity
Biological Processautophagy
Biological Processprotein transport
Biological Processproteolysis

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Cysteine protease
  • EC number

Gene names

    • Name
      Atg4b
    • ORF names
      ZEAMMB73_Zm00001d026641

Organism names

  • Taxonomic identifier
  • Organism
  • Taxonomic lineage
    Eukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > Liliopsida > Poales > Poaceae > PACMAD clade > Panicoideae > Andropogonodae > Andropogoneae > Tripsacinae > Zea

Accessions

  • Primary accession
    B8XVQ1

Subcellular Location

Keywords

Expression

Gene expression databases

Interaction

Subunit

Interacts with ATG8.

Family & Domains

Features

Showing features for region, domain.

Type
IDPosition(s)Description
Region1-51Disordered
Domain48-91Ig-like

Sequence similarities

Belongs to the peptidase C54 family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    208
  • Mass (Da)
    22,276
  • Last updated
    2009-03-03 v1
  • Checksum
    BC2A9D28F584F55A
MTTSPERGEAPPAPPRDSPCEDAAPAAAVVASSSSGSEREEDGGSRQPKASVLSGVFAPPLAIFEGQQQVSSTPCDASSTKPPSGSYAWSRILRRFVGSGSMWRLLGCARVLTSGDVWFLGKCYRVSPEEEESGGSDSDSGHAAFLEDFSSRIWITYRKGFDAIPGSKLTSDVNWGCMVRSSQMLVAQALIFHHLGRSWRKPSEKGCL

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
FJ445002
EMBL· GenBank· DDBJ
ACJ73916.1
EMBL· GenBank· DDBJ
mRNA
CM000786
EMBL· GenBank· DDBJ
AQK47330.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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