B8NSV5 · CREB_ASPFN
- ProteinProbable ubiquitin carboxyl-terminal hydrolase creB
- GenecreB
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids755 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
Ubiquitin thioesterase component of the regulatory network controlling carbon source utilization through ubiquitination and deubiquitination involving creA, creB, creC, creD and acrB. Deubiquitinates the creA catabolic repressor and the quinate permease qutD. Also plays a role in response to carbon starvation and the control of extracellular proteases activity (By similarity).
Catalytic activity
Features
Showing features for active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 64 | Nucleophile | ||||
Sequence: C | ||||||
Active site | 419 | Proton acceptor | ||||
Sequence: H |
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Cellular Component | nucleus | |
Molecular Function | cysteine-type deubiquitinase activity | |
Biological Process | carbon catabolite repression of transcription | |
Biological Process | protein deubiquitination | |
Biological Process | ubiquitin-dependent protein catabolic process |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameProbable ubiquitin carboxyl-terminal hydrolase creB
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Eurotiomycetes > Eurotiomycetidae > Eurotiales > Aspergillaceae > Aspergillus > Aspergillus subgen. Circumdati
Accessions
- Primary accessionB8NSV5
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000395679 | 1-755 | Probable ubiquitin carboxyl-terminal hydrolase creB | |||
Sequence: MGSFLRSLRRDVGPPTPSVGATPAKKEPPVPPVTPLEKMLQDMGAIREDGSDKFFGMENYGNTCYCNSILQCLYYSVPFREAVVNYPTRTPIESLEAALANTLRYQNFAANLEAEALAEKQKAANAQRPGAPPNQPQKPEDKDSPEYKKKMALQTLPLLETKNNATSYGMSESLFTSLKDLFESVVASQSRIGIIRPQHFLDVLRREHEMFRTAMHQDAHEFLNLLLNEVVANVEAEASKQPEPERSLPPAESADSTELSGSSGSKTPNTTRWVHELFEGTLTSETQCLTCEKVSQRDEVFLDLSVDLEQHSSVTSCLRKFSAEEMLCERNKFHCDNCGGLQEAEKRMKIKRLPRILALHLKRFKYTEDLQRLQKLFHRVVYPYHLRLFNTTDDAEDPDRLYELYAVVVHIGGGPYHGHYVAIIKTQDRGWLLFDDEMVEPVDKNYVRNFFGDRPGLACAYVLFYQETTLEAVMKEQEQENMDLNTSVADINDSTLKQNGYPLSPGLAHVHSASQIPSPSEPARFSNLQRAPTAPPLFPHPEHADSESSPADPSTTASATPPVPPIPDIHSLPLSPKKSDSHFKKERAKEEKERKANEKEKEKQRRRDQEARIREQRREDAEIRAALEASKASKAEEDRRHSPDDTKKSSHGLSRLKRGSKSFSHRLGKDKENRVSSSSHSATPIAEHPPSRNGASESQQQLPNGQSPGSHGLHTRHTGLDEERDTLKDPKHDRSGHHGKWRSFSLKKKSFSILS |
Interaction
Structure
Family & Domains
Features
Showing features for region, domain, compositional bias, coiled coil.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-32 | Disordered | ||||
Sequence: MGSFLRSLRRDVGPPTPSVGATPAKKEPPVPP | ||||||
Domain | 55-468 | USP | ||||
Sequence: FGMENYGNTCYCNSILQCLYYSVPFREAVVNYPTRTPIESLEAALANTLRYQNFAANLEAEALAEKQKAANAQRPGAPPNQPQKPEDKDSPEYKKKMALQTLPLLETKNNATSYGMSESLFTSLKDLFESVVASQSRIGIIRPQHFLDVLRREHEMFRTAMHQDAHEFLNLLLNEVVANVEAEASKQPEPERSLPPAESADSTELSGSSGSKTPNTTRWVHELFEGTLTSETQCLTCEKVSQRDEVFLDLSVDLEQHSSVTSCLRKFSAEEMLCERNKFHCDNCGGLQEAEKRMKIKRLPRILALHLKRFKYTEDLQRLQKLFHRVVYPYHLRLFNTTDDAEDPDRLYELYAVVVHIGGGPYHGHYVAIIKTQDRGWLLFDDEMVEPVDKNYVRNFFGDRPGLACAYVLFYQET | ||||||
Region | 119-146 | Disordered | ||||
Sequence: EKQKAANAQRPGAPPNQPQKPEDKDSPE | ||||||
Region | 237-270 | Disordered | ||||
Sequence: EASKQPEPERSLPPAESADSTELSGSSGSKTPNT | ||||||
Compositional bias | 253-270 | Polar residues | ||||
Sequence: SADSTELSGSSGSKTPNT | ||||||
Region | 495-755 | Disordered | ||||
Sequence: TLKQNGYPLSPGLAHVHSASQIPSPSEPARFSNLQRAPTAPPLFPHPEHADSESSPADPSTTASATPPVPPIPDIHSLPLSPKKSDSHFKKERAKEEKERKANEKEKEKQRRRDQEARIREQRREDAEIRAALEASKASKAEEDRRHSPDDTKKSSHGLSRLKRGSKSFSHRLGKDKENRVSSSSHSATPIAEHPPSRNGASESQQQLPNGQSPGSHGLHTRHTGLDEERDTLKDPKHDRSGHHGKWRSFSLKKKSFSILS | ||||||
Compositional bias | 511-527 | Polar residues | ||||
Sequence: HSASQIPSPSEPARFSN | ||||||
Compositional bias | 557-571 | Pro residues | ||||
Sequence: ASATPPVPPIPDIHS | ||||||
Compositional bias | 575-652 | Basic and acidic residues | ||||
Sequence: SPKKSDSHFKKERAKEEKERKANEKEKEKQRRRDQEARIREQRREDAEIRAALEASKASKAEEDRRHSPDDTKKSSHG | ||||||
Coiled coil | 581-630 | |||||
Sequence: SHFKKERAKEEKERKANEKEKEKQRRRDQEARIREQRREDAEIRAALEAS | ||||||
Compositional bias | 677-713 | Polar residues | ||||
Sequence: SSSHSATPIAEHPPSRNGASESQQQLPNGQSPGSHGL | ||||||
Compositional bias | 715-740 | Basic and acidic residues | ||||
Sequence: TRHTGLDEERDTLKDPKHDRSGHHGK |
Sequence similarities
Belongs to the peptidase C19 family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length755
- Mass (Da)85,064
- Last updated2009-03-03 v1
- ChecksumFA0FB9C8256630C4
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 253-270 | Polar residues | ||||
Sequence: SADSTELSGSSGSKTPNT | ||||||
Compositional bias | 511-527 | Polar residues | ||||
Sequence: HSASQIPSPSEPARFSN | ||||||
Compositional bias | 557-571 | Pro residues | ||||
Sequence: ASATPPVPPIPDIHS | ||||||
Compositional bias | 575-652 | Basic and acidic residues | ||||
Sequence: SPKKSDSHFKKERAKEEKERKANEKEKEKQRRRDQEARIREQRREDAEIRAALEASKASKAEEDRRHSPDDTKKSSHG | ||||||
Compositional bias | 677-713 | Polar residues | ||||
Sequence: SSSHSATPIAEHPPSRNGASESQQQLPNGQSPGSHGL | ||||||
Compositional bias | 715-740 | Basic and acidic residues | ||||
Sequence: TRHTGLDEERDTLKDPKHDRSGHHGK |
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
EQ963483 EMBL· GenBank· DDBJ | EED47094.1 EMBL· GenBank· DDBJ | Genomic DNA |