B8N7E5 · RSP5_ASPFN
- ProteinProbable E3 ubiquitin-protein ligase hulA
- GenehulA
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids812 (go to sequence)
- Protein existenceInferred from homology
- Annotation score5/5
Function
function
E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Probably involved in the regulatory network controlling carbon source utilization.
Catalytic activity
Pathway
Protein modification; protein ubiquitination.
Features
Showing features for active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 780 | Glycyl thioester intermediate | ||||
Sequence: C |
GO annotations
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameProbable E3 ubiquitin-protein ligase hulA
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Eurotiomycetes > Eurotiomycetidae > Eurotiales > Aspergillaceae > Aspergillus > Aspergillus subgen. Circumdati
Accessions
- Primary accessionB8N7E5
Organism-specific databases
Subcellular Location
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000395705 | 1-812 | Probable E3 ubiquitin-protein ligase hulA | |||
Sequence: MTCSQPNLRVTIIAADGLYKRDVFRFPDPFAVATVGGEQTHTTSVIKKTLNPYWNEMFDLRVNEDSILAIQIFDQKKFKKKDQGFLGVINVRIGDVIDLQMGGDEMLTRDLKKSNDNLVVHGKLIINLSTNLSTPNTNQANGLHRSHMQPSTSSGLVPQVSASTPQPSPGPSQADPTASNPSLHPQRVPSTTRPSSTIVPANGPPAPPNGQQGSRTNLSSFEDSQGRLPAGWERREDNLGRTYYVDHNTRTTTWTRPSNNYNEQTSRTQREASMQLERRAHQSRMLPEDRTGASSPNLQENQQQAQTPPAGGSASAVSMMATGATTAGTGELPPGWEQRTTPEGRPYFVDHNTRTTTWVDPRRQQYIRMYGQNANGTNTTIQQQPVSQLGPLPSGWEMRLTNTARVYFVDHNTKTTTWDDPRLPSSLDQGVPQYKRDFRRKLIYFRSQPALRIMSGQCHVKVRRNNIFEDSYAEIMRQSASDLKKRLMIKFDGEDGLDYGGLSREFFFLLSHEMFNPFYCLFEYSAHDNYTLQINPHSGVNPEHLNYFKFIGRVVGLAIFHRRFLDSFFIGAFYKMMLRKKVSLQDMEGVDEDLHRNLTWTLDNDIEGIIELTFAVDDEKFGERRTIDLKPGGRDIPVTNENKGEYVELVTEWKIVKRVEEQFNAFMSGFNELIPADLVNVFDERELELLIGGIADIDVDDWKKHTDYRGYQESDEVIQNFWKIVRTWDAEQKSRLLQFTTGTSRIPVNGFKDLQGSDGPRRFTIEKSGDPGALPKSHTCFNRLDLPPYKTNDVLEHKLSIAVEETLGFGQE |
Interaction
Structure
Family & Domains
Features
Showing features for domain, compositional bias, region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 1-109 | C2 | ||||
Sequence: MTCSQPNLRVTIIAADGLYKRDVFRFPDPFAVATVGGEQTHTTSVIKKTLNPYWNEMFDLRVNEDSILAIQIFDQKKFKKKDQGFLGVINVRIGDVIDLQMGGDEMLTR | ||||||
Compositional bias | 131-168 | Polar residues | ||||
Sequence: NLSTPNTNQANGLHRSHMQPSTSSGLVPQVSASTPQPS | ||||||
Region | 131-235 | Disordered | ||||
Sequence: NLSTPNTNQANGLHRSHMQPSTSSGLVPQVSASTPQPSPGPSQADPTASNPSLHPQRVPSTTRPSSTIVPANGPPAPPNGQQGSRTNLSSFEDSQGRLPAGWERR | ||||||
Compositional bias | 175-199 | Polar residues | ||||
Sequence: DPTASNPSLHPQRVPSTTRPSSTIV | ||||||
Compositional bias | 208-224 | Polar residues | ||||
Sequence: PNGQQGSRTNLSSFEDS | ||||||
Domain | 226-259 | WW 1 | ||||
Sequence: GRLPAGWERREDNLGRTYYVDHNTRTTTWTRPSN | ||||||
Compositional bias | 250-271 | Polar residues | ||||
Sequence: RTTTWTRPSNNYNEQTSRTQRE | ||||||
Region | 250-350 | Disordered | ||||
Sequence: RTTTWTRPSNNYNEQTSRTQREASMQLERRAHQSRMLPEDRTGASSPNLQENQQQAQTPPAGGSASAVSMMATGATTAGTGELPPGWEQRTTPEGRPYFVD | ||||||
Compositional bias | 272-286 | Basic and acidic residues | ||||
Sequence: ASMQLERRAHQSRML | ||||||
Compositional bias | 288-325 | Polar residues | ||||
Sequence: EDRTGASSPNLQENQQQAQTPPAGGSASAVSMMATGAT | ||||||
Domain | 330-363 | WW 2 | ||||
Sequence: GELPPGWEQRTTPEGRPYFVDHNTRTTTWVDPRR | ||||||
Domain | 390-423 | WW 3 | ||||
Sequence: GPLPSGWEMRLTNTARVYFVDHNTKTTTWDDPRL | ||||||
Domain | 479-812 | HECT | ||||
Sequence: SASDLKKRLMIKFDGEDGLDYGGLSREFFFLLSHEMFNPFYCLFEYSAHDNYTLQINPHSGVNPEHLNYFKFIGRVVGLAIFHRRFLDSFFIGAFYKMMLRKKVSLQDMEGVDEDLHRNLTWTLDNDIEGIIELTFAVDDEKFGERRTIDLKPGGRDIPVTNENKGEYVELVTEWKIVKRVEEQFNAFMSGFNELIPADLVNVFDERELELLIGGIADIDVDDWKKHTDYRGYQESDEVIQNFWKIVRTWDAEQKSRLLQFTTGTSRIPVNGFKDLQGSDGPRRFTIEKSGDPGALPKSHTCFNRLDLPPYKTNDVLEHKLSIAVEETLGFGQE |
Sequence similarities
Belongs to the RSP5/NEDD4 family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length812
- Mass (Da)92,148
- Last updated2009-03-03 v1
- Checksum0D0244666099CC99
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 131-168 | Polar residues | ||||
Sequence: NLSTPNTNQANGLHRSHMQPSTSSGLVPQVSASTPQPS | ||||||
Compositional bias | 175-199 | Polar residues | ||||
Sequence: DPTASNPSLHPQRVPSTTRPSSTIV | ||||||
Compositional bias | 208-224 | Polar residues | ||||
Sequence: PNGQQGSRTNLSSFEDS | ||||||
Compositional bias | 250-271 | Polar residues | ||||
Sequence: RTTTWTRPSNNYNEQTSRTQRE | ||||||
Compositional bias | 272-286 | Basic and acidic residues | ||||
Sequence: ASMQLERRAHQSRML | ||||||
Compositional bias | 288-325 | Polar residues | ||||
Sequence: EDRTGASSPNLQENQQQAQTPPAGGSASAVSMMATGAT |
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
EQ963474 EMBL· GenBank· DDBJ | EED54915.1 EMBL· GenBank· DDBJ | Genomic DNA |