B8LDL7 · B8LDL7_THAPS

Function

function

IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The glutaminase domain produces the ammonia necessary for the cyclase domain to produce IGP and AICAR from PRFAR. The ammonia is channeled to the active site of the cyclase domain.

Catalytic activity

Pathway

Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 5/9.

Features

Showing features for active site, binding site.

Type
IDPosition(s)Description
Active site86For GATase activity
Active site86Nucleophile
Binding site86L-glutamine (UniProtKB | ChEBI); covalent
Active site204
Active site204For GATase activity
Active site206
Active site206For GATase activity
Active site253
Binding site346substrate
Active site419
Binding site488substrate

GO annotations

AspectTerm
Molecular Functionglutaminase activity
Molecular Functionimidazoleglycerol-phosphate synthase activity
Molecular Functionoxo-acid-lyase activity
Biological Processglutamine metabolic process
Biological ProcessL-histidine biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Imidazole glycerol phosphate synthase hisHF

Including 2 domains:

  • Recommended name
    Glutaminase
  • EC number
  • Recommended name
    Cyclase

Gene names

    • Name
      hisH
    • ORF names
      THAPSDRAFT_30478

Organism names

Accessions

  • Primary accession
    B8LDL7

Proteomes

PTM/Processing

Proteomic databases

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain, region.

Type
IDPosition(s)Description
Domain11-209Glutamine amidotransferase
Region379-380PRFAR binding
Region417-419PRFAR binding
Region493-494PRFAR binding
Region519-520PRFAR binding
Region542-543PRFAR binding

Sequence similarities

Belongs to the HisA/HisF family.
In the C-terminal section; belongs to the HisA/HisF family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    570
  • Mass (Da)
    61,675
  • Last updated
    2009-03-03 v1
  • Checksum
    A191765E36D45EDA
MTTRTKPTVSLLDYGAGNVRSVRNAITSTGYTLIDISSPSQILTADVIIFPGVGSYASAMEVLKREGYDVALKEYLKMNKPFLGICLGMQTLFESSQECGHNGDGMTSTMIEGLGVIPGKVVKFNEQERSVPHIGWNGALRHQSSPCMRYIHDNSHGEEVYFVHSYYAPLTAENSEWVLTRTTYEGQEFISSVQKGNVVATQFHPEKSGVTGLNFIRGFLDSVADGTLSNTQPLEVDGSKHTELVKRVVVALDVRSNDHGDLVVTKGDQYDVRENEKEGVQEGRGGVRNLGKPVSLASRYYKEGADEIAFLNITSFRSGVIEDMPMLQVLEEASKEIFVPLTVGGGIRSYEDPGTGKVYSALEVASRYFRAGADKVSIGSDSVHAAEEYIASGNTKTGQTSIETISHVYGVQAVVISIDPKRVYVTSPDAADSKHTVVTLDDSQKGPNGEQYCWYQCTVKGGREARDICAVSVAKAAEALGAGEIMLNCIDMDGQCNGFDHALMKAVSDAVTIPVIASSGAGKESHFSDVFSETSVQAALAAGMFHRKEVEIADVKKHMEKMGIRARITG

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
DS999420
EMBL· GenBank· DDBJ
EED86571.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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