B8JK22 · B8JK22_DANRE

Function

function

Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation.

Catalytic activity

  • (5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate
    This reaction proceeds in the forward direction.
    EC:6.2.1.15 (UniProtKB | ENZYME | Rhea)
  • (E)-hexadec-2-enoate + ATP + CoA = (2E)-hexadecenoyl-CoA + AMP + diphosphate
    This reaction proceeds in the forward direction.
  • 12-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + ATP + CoA = 12-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate
    This reaction proceeds in the forward direction.
  • 15-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + ATP + CoA = 15-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl-CoA + AMP + diphosphate
    This reaction proceeds in the forward direction.
  • 5-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = 5-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate
    This reaction proceeds in the forward direction.
  • ATP + CoA + hexadecanoate = AMP + diphosphate + hexadecanoyl-CoA
    This reaction proceeds in the forward direction.
  • a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate
    This reaction proceeds in the forward direction.
    EC:6.2.1.3 (UniProtKB | ENZYME | Rhea)

GO annotations

AspectTerm
Cellular Componentendoplasmic reticulum
Cellular Componentmembrane
Molecular Functionarachidonate-CoA ligase activity
Molecular FunctionATP binding
Biological Processlong-chain fatty acid metabolic process
Biological Processlong-chain fatty-acyl-CoA biosynthetic process
Biological Processvery long-chain fatty acid metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Long-chain-fatty-acid--CoA ligase
  • EC number

Gene names

    • Name
      acsl1a
    • Synonyms
      acsl1
      , zgc:110081

Organism names

  • Taxonomic identifier
  • Strain
    • Tuebingen
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Cypriniformes > Danionidae > Danioninae > Danio

Accessions

  • Primary accession
    B8JK22
  • Secondary accessions
    • A0A8M2BFN5

Proteomes

Organism-specific databases

Subcellular Location

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane21-45Helical

Keywords

  • Cellular component

PTM/Processing

Proteomic databases

Expression

Gene expression databases

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain117-519AMP-dependent synthetase/ligase

Sequence similarities

Belongs to the ATP-dependent AMP-binding enzyme family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    697
  • Mass (Da)
    77,439
  • Last updated
    2009-03-03 v1
  • Checksum
    688EBD2CC4C96816
MQAQDLIRHLRMPELDDLRQYVRSLPTNTLMGMGAFAAITTYWLATRPKALKPPCDLTMQSVEVPGKEYARRSILMDNDTHMTYYYKDALTLYEFFLRGLRVSNNGPCLGSRKAGQPYKWLSYKEVADRAEFAGSALLHRGHSQSGDKYIGIFAQNRPEWTISELACYTYSLVAVPLYDTLGTEAISYVIDKASITTIICDIADKARLILDCVSGRKHSVTTIVIMESFDSELTAQAQNCGIDIISLKELEAIGKANHKTPIPPKPEDLALICFTSGTTGNPKGAMLTHGNVVSNCSAFIKITEVHCMLNQTDIHISYLPLAHMFERVVEGVLLCHGAKIGYFQGDIRLLMDDLKNLKPTIFPVVPRLLNRMFDKIFGQANTPLKRWLLDFATSRKEAELKSGVVRKDSMWDKLIFSKVQASLGGRVRLMITGAAPVSPTVLTFLRAALGCQFYEGYGQTECTAGCTMSLPGDWTAGHVGAPLPCNFVKLVDVAEMNYFAANGEGEVCVKGPNVFQGYLKDPEQTSGAVDKAGWLHTGDIGKWLPNGTLKIIDRKKHIFKLAQGEYIAPEKIENIYIRSDPVAQVFVHGDSLQACLVGVVVPDPDFLPGWAKNRGIEGSFNDLCKSKEVKNAILEDMIQLGKEAGLKSFEQVRDIALHLEMFSVQNGLLTPTLKAKRTELKSRFREQIDQLYAKIKM

Computationally mapped potential isoform sequences

There are 2 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A8M2BFN1A0A8M2BFN1_DANREacsl1a697
Q499A9Q499A9_DANREacsl1a697

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
BX537280
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.

Genome annotation databases

Similar Proteins

Disclaimer

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