B8JFS8 · SYY_ANAD2
- ProteinTyrosine--tRNA ligase
- GenetyrS
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids420 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
Catalytic activity
- tRNA(Tyr) + L-tyrosine + ATP = L-tyrosyl-tRNA(Tyr) + AMP + diphosphate + H+
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 33 | L-tyrosine (UniProtKB | ChEBI) | |||
Binding site | 167 | L-tyrosine (UniProtKB | ChEBI) | |||
Binding site | 171 | L-tyrosine (UniProtKB | ChEBI) | |||
Binding site | 230 | ATP (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | ATP binding | |
Molecular Function | RNA binding | |
Molecular Function | tyrosine-tRNA ligase activity | |
Biological Process | tyrosyl-tRNA aminoacylation |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameTyrosine--tRNA ligase
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Myxococcota > Myxococcia > Myxococcales > Cystobacterineae > Anaeromyxobacteraceae > Anaeromyxobacter
Accessions
- Primary accessionB8JFS8
Proteomes
Subcellular Location
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_1000189255 | 1-420 | Tyrosine--tRNA ligase | ||
Interaction
Subunit
Homodimer.
Structure
Family & Domains
Features
Showing features for motif, domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Motif | 38-47 | 'HIGH' region | |||
Motif | 227-231 | 'KMSKS' region | |||
Domain | 353-419 | S4 RNA-binding | |||
Sequence similarities
Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length420
- Mass (Da)45,319
- Last updated2009-03-03 v1
- MD5 ChecksumFBE4EA701A4EB92E9D881C21403A7397
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP001359 EMBL· GenBank· DDBJ | ACL64516.1 EMBL· GenBank· DDBJ | Genomic DNA |