B8JDF0 · PYRD_ANAD2
- ProteinDihydroorotate dehydrogenase (quinone)
- GenepyrD
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids364 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
Catalytic activity
- (S)-dihydroorotate + a quinone = a quinol + orotate
Cofactor
Note: Binds 1 FMN per subunit.
Pathway
Pyrimidine metabolism; UMP biosynthesis via de novo pathway; orotate from (S)-dihydroorotate (quinone route): step 1/1.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 62-66 | FMN (UniProtKB | ChEBI) | ||||
Sequence: AGFDK | ||||||
Binding site | 66 | substrate | ||||
Sequence: K | ||||||
Binding site | 86 | FMN (UniProtKB | ChEBI) | ||||
Sequence: T | ||||||
Binding site | 111-115 | substrate | ||||
Sequence: NRMGF | ||||||
Binding site | 142 | FMN (UniProtKB | ChEBI) | ||||
Sequence: N | ||||||
Binding site | 175 | FMN (UniProtKB | ChEBI) | ||||
Sequence: N | ||||||
Binding site | 175 | substrate | ||||
Sequence: N | ||||||
Active site | 178 | Nucleophile | ||||
Sequence: S | ||||||
Binding site | 180 | substrate | ||||
Sequence: N | ||||||
Binding site | 216 | FMN (UniProtKB | ChEBI) | ||||
Sequence: K | ||||||
Binding site | 244 | FMN (UniProtKB | ChEBI) | ||||
Sequence: T | ||||||
Binding site | 245-246 | substrate | ||||
Sequence: NT | ||||||
Binding site | 267 | FMN (UniProtKB | ChEBI) | ||||
Sequence: G | ||||||
Binding site | 296 | FMN (UniProtKB | ChEBI) | ||||
Sequence: G | ||||||
Binding site | 317-318 | FMN (UniProtKB | ChEBI) | ||||
Sequence: YT |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | plasma membrane | |
Molecular Function | dihydroorotate dehydrogenase (quinone) activity | |
Biological Process | 'de novo' pyrimidine nucleobase biosynthetic process | |
Biological Process | 'de novo' UMP biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameDihydroorotate dehydrogenase (quinone)
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Myxococcota > Myxococcia > Myxococcales > Cystobacterineae > Anaeromyxobacteraceae > Anaeromyxobacter
Accessions
- Primary accessionB8JDF0
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Peripheral membrane protein
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_1000195061 | 1-364 | Dihydroorotate dehydrogenase (quinone) | |||
Sequence: MLWPALRSVLFQLDPERVHHLAHWALHRVPLAVARARRPASIPALAVRCMGLDFDGPVGLAAGFDKGDVALPGLFGLGFSHVEIGTITPRPQPGNDRPRLFRLPEHRALLNRMGFNNEGMEACARRLAALPPAARLGPVGINVGKNKVTPNEDAAADYLACIERLHPYADYLVVNISSPNTPGLRQLQERDALDRLLRACVRHLAERAPGKPLLVKLAPDLSPEALDEAVDVAIAAGAAGIVATNTTLSRAGVERHPRAAEAGGLSGAPLERLATDVVRRCYARAAGRVPIVGVGGVMDAEGAYAKIRAGATLVQAYTGLIYGGPAFVGRVNAGLARLLERDGFSTLSDAVGADHRQGGGKAAG |
Interaction
Subunit
Monomer.
Structure
Sequence
- Sequence statusComplete
- Length364
- Mass (Da)38,376
- Last updated2009-03-03 v1
- Checksum4FA5E92CBF9D9A95
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP001359 EMBL· GenBank· DDBJ | ACL65999.1 EMBL· GenBank· DDBJ | Genomic DNA |