B8JDF0 · PYRD_ANAD2

Function

function

Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.

Catalytic activity

Cofactor

FMN (UniProtKB | Rhea| CHEBI:58210 )

Note: Binds 1 FMN per subunit.

Pathway

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; orotate from (S)-dihydroorotate (quinone route): step 1/1.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site62-66FMN (UniProtKB | ChEBI)
Binding site66substrate
Binding site86FMN (UniProtKB | ChEBI)
Binding site111-115substrate
Binding site142FMN (UniProtKB | ChEBI)
Binding site175FMN (UniProtKB | ChEBI)
Binding site175substrate
Active site178Nucleophile
Binding site180substrate
Binding site216FMN (UniProtKB | ChEBI)
Binding site244FMN (UniProtKB | ChEBI)
Binding site245-246substrate
Binding site267FMN (UniProtKB | ChEBI)
Binding site296FMN (UniProtKB | ChEBI)
Binding site317-318FMN (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componentplasma membrane
Molecular Functiondihydroorotate dehydrogenase (quinone) activity
Biological Process'de novo' pyrimidine nucleobase biosynthetic process
Biological Process'de novo' UMP biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Dihydroorotate dehydrogenase (quinone)
  • EC number
  • Alternative names
    • DHOdehase
      (DHOD
      ; DHODase
      )
    • Dihydroorotate oxidase

Gene names

    • Name
      pyrD
    • Ordered locus names
      A2cp1_2662

Organism names

Accessions

  • Primary accession
    B8JDF0

Proteomes

Subcellular Location

Cell membrane
; Peripheral membrane protein

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_10001950611-364Dihydroorotate dehydrogenase (quinone)

Interaction

Subunit

Monomer.

Structure

Family & Domains

Sequence similarities

Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    364
  • Mass (Da)
    38,376
  • Last updated
    2009-03-03 v1
  • Checksum
    4FA5E92CBF9D9A95
MLWPALRSVLFQLDPERVHHLAHWALHRVPLAVARARRPASIPALAVRCMGLDFDGPVGLAAGFDKGDVALPGLFGLGFSHVEIGTITPRPQPGNDRPRLFRLPEHRALLNRMGFNNEGMEACARRLAALPPAARLGPVGINVGKNKVTPNEDAAADYLACIERLHPYADYLVVNISSPNTPGLRQLQERDALDRLLRACVRHLAERAPGKPLLVKLAPDLSPEALDEAVDVAIAAGAAGIVATNTTLSRAGVERHPRAAEAGGLSGAPLERLATDVVRRCYARAAGRVPIVGVGGVMDAEGAYAKIRAGATLVQAYTGLIYGGPAFVGRVNAGLARLLERDGFSTLSDAVGADHRQGGGKAAG

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP001359
EMBL· GenBank· DDBJ
ACL65999.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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