B8JBM1 · DNLI_ANAD2

Function

function

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.

Catalytic activity

  • ATP + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m = (deoxyribonucleotide)n+m + AMP + diphosphate.
    EC:6.5.1.1 (UniProtKB | ENZYME | Rhea)

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Features

Showing features for binding site, active site.

151350100150200250300350400450500
Type
IDPosition(s)Description
Binding site213ATP (UniProtKB | ChEBI)
Active site215N6-AMP-lysine intermediate
Binding site220ATP (UniProtKB | ChEBI)
Binding site235ATP (UniProtKB | ChEBI)
Binding site264ATP (UniProtKB | ChEBI)
Binding site304ATP (UniProtKB | ChEBI)
Binding site376ATP (UniProtKB | ChEBI)
Binding site382ATP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular FunctionATP binding
Molecular FunctionDNA binding
Molecular FunctionDNA ligase (ATP) activity
Molecular Functionmetal ion binding
Biological Processcell division
Biological ProcessDNA biosynthetic process
Biological ProcessDNA ligation
Biological ProcessDNA recombination
Biological ProcessDNA repair
Biological ProcessDNA replication

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Probable DNA ligase
  • EC number
  • Alternative names
    • Polydeoxyribonucleotide synthase [ATP]

Gene names

    • Name
      lig
    • Ordered locus names
      A2cp1_4312

Organism names

Accessions

  • Primary accession
    B8JBM1

Proteomes

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_10001347251-513Probable DNA ligase

Structure

Family & Domains

Sequence similarities

Belongs to the ATP-dependent DNA ligase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    513
  • Mass (Da)
    54,060
  • Last updated
    2009-03-03 v1
  • Checksum
    A4CCC38389CAB126
MLLAELAEVSRAVAATPARLEKIARLAEALRRLAPDERAVGASWLAGDLPGGRIGIGGATVRAALDAAPAEGGGPGLTVAEVDAALGRIATASGAGSAGARRRELDALLARAGAPERWFLAALLLGELRQGALEGVLADAVARAAGLPAAEVRRAAMLAGALPPVAVAALSEGAAGLARFRLRVGEPVSPMLAQTAADVEEALRALGGEAALEWKLDGARIQAHRDGGEVRVFSRSLRDVTAAVPEVVALLRAAPEPRLVLDGEAIALRADGTPEPFQVTMRRFGRRLDVERLAPDLPLTAFFFDALVAGGAELLASPERVRWAALERAVPAEQRVPRLVTRDPAEAGAFLEDALARGQEGVVAKALDAPYEAGRRGAAWLKVKRAHTLDLVVLAAEWGSGRRRGWLSNLHLGARDPSTGGFVMLGKTFKGMTDAMLAWQTERLKALATGPLDAWQVPVRPELVVEVAFDGIQSSPRYPGGLALRFARVKRYREDKRPEDADTIETVRGLYGG

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP001359
EMBL· GenBank· DDBJ
ACL67629.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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