B8JAN5 · DAPA_ANAD2
- Protein4-hydroxy-tetrahydrodipicolinate synthase
- GenedapA
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids295 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
Catalytic activity
- L-aspartate 4-semialdehyde + pyruvate = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H2O + H+
Pathway
Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 3/4.
Features
Showing features for site, binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Site | 45 | Part of a proton relay during catalysis | |||
Binding site | 46 | pyruvate (UniProtKB | ChEBI) | |||
Site | 108 | Part of a proton relay during catalysis | |||
Active site | 134 | Proton donor/acceptor | |||
Active site | 162 | Schiff-base intermediate with substrate | |||
Binding site | 205 | pyruvate (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | 4-hydroxy-tetrahydrodipicolinate synthase activity | |
Biological Process | diaminopimelate biosynthetic process | |
Biological Process | lysine biosynthetic process via diaminopimelate |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended name4-hydroxy-tetrahydrodipicolinate synthase
- EC number
- Short namesHTPA synthase
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Myxococcota > Myxococcia > Myxococcales > Cystobacterineae > Anaeromyxobacteraceae > Anaeromyxobacter
Accessions
- Primary accessionB8JAN5
Proteomes
Subcellular Location
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_1000134855 | 1-295 | 4-hydroxy-tetrahydrodipicolinate synthase | ||
Interaction
Subunit
Homotetramer; dimer of dimers.
Structure
Sequence
- Sequence statusComplete
- Length295
- Mass (Da)31,069
- Last updated2009-03-03 v1
- ChecksumCED52E094FD83290
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP001359 EMBL· GenBank· DDBJ | ACL67534.1 EMBL· GenBank· DDBJ | Genomic DNA |