B8J7G1 · PCKG_ANAD2

Function

function

Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.

Catalytic activity

Cofactor

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Note: Binds 1 Mn2+ ion per subunit.

Pathway

Carbohydrate biosynthesis; gluconeogenesis.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site77substrate
Binding site205-207substrate
Binding site214Mn2+ (UniProtKB | ChEBI)
Binding site234Mn2+ (UniProtKB | ChEBI)
Binding site256substrate
Binding site257-262GTP (UniProtKB | ChEBI)
Active site258
Binding site283Mn2+ (UniProtKB | ChEBI)
Binding site373-375substrate
Binding site375GTP (UniProtKB | ChEBI)
Binding site406GTP (UniProtKB | ChEBI)
Binding site499-502GTP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular FunctionGTP binding
Molecular Functionmanganese ion binding
Molecular Functionphosphoenolpyruvate carboxykinase (GTP) activity
Biological Processcellular response to glucose stimulus
Biological Processgluconeogenesis
Biological Processglycerol biosynthetic process from pyruvate
Biological Processpropionate catabolic process
Biological Processresponse to lipid
Biological Processresponse to starvation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Phosphoenolpyruvate carboxykinase [GTP]
  • EC number
  • Short names
    PEP carboxykinase
    ; PEPCK

Gene names

    • Name
      pckG
    • Ordered locus names
      A2cp1_3817

Organism names

Accessions

  • Primary accession
    B8J7G1

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_10001923431-596Phosphoenolpyruvate carboxykinase [GTP]

Interaction

Subunit

Monomer.

Structure

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region362-388Disordered

Sequence similarities

Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    596
  • Mass (Da)
    65,869
  • Last updated
    2009-03-03 v1
  • Checksum
    053D58D526ECC4A9
MSTSPAARPTSNAHLLGWVDEMAKLCKPDRVYWCDGSEAEKKRLTDDAVAAKVLIPLDQQKWPGCHYHHSNSSDVARVEHLTFICTPTKEQAGPTNNWMEPKEAYRKLGAIFDGSMKGRTMYVVPYVMGPSTSPFAKVGIEITDSVYVALNMGIMARMGKVALDRLGDSDEFNRGLHSVADCNPERRFICHFPQDNTIWSVGSGYGGNALLGKKCLALRIASYLAKNEGWLAEHMLILEAESPTGEKQYVAAAFPSACGKTNFAMMIPPAAFPGWKIRTVGDDISWMRVGEDGRLWAVNPENGYFGVAPGTNRKTNPNAMDSVRKDTIFTNVARTPDGDIWWEGMDHEAPAELIDWKGQPWKKGSTEKAAHPNSRFTAPAKNNPAISPLVDDPKGVPISAIIFGGRRSTTVPLVLEAFNWTHGVYLGSTMGSETTAAATGQVGVVRRDPMAMLPFIGYDCGSYLQHWLDMQSRIPNPPKIFLVNWFRKSAEGKFLWPGYGDNMRVLKWMLDRAAGRAPAKETLLGYTPGDSGLDLHGLDVSKDAIAAATQIDLGEWEQELESQSEWFEKLGKTLPRPLALQRELLLERVRAARKVK

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP001359
EMBL· GenBank· DDBJ
ACL67141.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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