B8J4Q3 · AROC_DESDA
- ProteinChorismate synthase
- GenearoC
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids364 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
Catalytic activity
- 5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate
Cofactor
Note: Reduced FMN (FMNH2).
Pathway
Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 7/7.
Features
Showing features for binding site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | chorismate synthase activity | |
Molecular Function | FMN binding | |
Biological Process | amino acid biosynthetic process | |
Biological Process | aromatic amino acid family biosynthetic process | |
Biological Process | chorismate biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameChorismate synthase
- EC number
- Short namesCS
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Thermodesulfobacteriota > Desulfovibrionia > Desulfovibrionales > Desulfovibrionaceae > Desulfovibrio
Accessions
- Primary accessionB8J4Q3
Subcellular Location
UniProt Annotation
GO Annotation
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_1000132766 | 1-364 | Chorismate synthase | |||
Sequence: MAGNTFGRALRLTTFGESHGPGLGGIIDGCPAGLELTEAHIQAELDRRKPGQGPTATKRKEADTVRLLSGVFEGCTTGTPIAFFIANEDQRSRDYGNLAEAFRPGHADWAYFQKYNGLRDHRGGGRSSGRETAARVAGGVIAKKILARRGVTILGGCVELGGIAAPLWGLDMDGAAARPYCAAAPSVVSQWDALVAEARKAGETLGGIVRIEAHNVPAGLGEPVFDKLDAVLAHAVMSVGAVKGVEVGEGFAAAALRGSQNNDPLLPADAPEPGRARFASNHAGGILGGISSGQDIVLRVAVKPIASIAVTQKTVDRQGQPVDILIGGRHDLSAIPRIVPVLEAMTALALADALLLQQRMGLGL |
Interaction
Structure
Sequence
- Sequence statusComplete
- Length364
- Mass (Da)37,686
- Last updated2009-03-03 v1
- ChecksumCA54B5E56F03B57E
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP001358 EMBL· GenBank· DDBJ | ACL50183.1 EMBL· GenBank· DDBJ | Genomic DNA |