B8J4Q3 · AROC_DESDA

Function

function

Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.

Catalytic activity

Cofactor

FMNH2 (UniProtKB | Rhea| CHEBI:57618 )

Note: Reduced FMN (FMNH2).

Pathway

Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 7/7.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site48NADP+ (UniProtKB | ChEBI)
Binding site126-128FMN (UniProtKB | ChEBI)
Binding site288FMN (UniProtKB | ChEBI)
Binding site303-307FMN (UniProtKB | ChEBI)
Binding site329FMN (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Functionchorismate synthase activity
Molecular FunctionFMN binding
Biological Processamino acid biosynthetic process
Biological Processaromatic amino acid family biosynthetic process
Biological Processchorismate biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Chorismate synthase
  • EC number
  • Short names
    CS
  • Alternative names
    • 5-enolpyruvylshikimate-3-phosphate phospholyase

Gene names

    • Name
      aroC
    • Ordered locus names
      Ddes_2288

Organism names

Accessions

  • Primary accession
    B8J4Q3

Subcellular Location

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_10001327661-364Chorismate synthase

Interaction

Subunit

Homotetramer.

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Belongs to the chorismate synthase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    364
  • Mass (Da)
    37,686
  • Last updated
    2009-03-03 v1
  • Checksum
    CA54B5E56F03B57E
MAGNTFGRALRLTTFGESHGPGLGGIIDGCPAGLELTEAHIQAELDRRKPGQGPTATKRKEADTVRLLSGVFEGCTTGTPIAFFIANEDQRSRDYGNLAEAFRPGHADWAYFQKYNGLRDHRGGGRSSGRETAARVAGGVIAKKILARRGVTILGGCVELGGIAAPLWGLDMDGAAARPYCAAAPSVVSQWDALVAEARKAGETLGGIVRIEAHNVPAGLGEPVFDKLDAVLAHAVMSVGAVKGVEVGEGFAAAALRGSQNNDPLLPADAPEPGRARFASNHAGGILGGISSGQDIVLRVAVKPIASIAVTQKTVDRQGQPVDILIGGRHDLSAIPRIVPVLEAMTALALADALLLQQRMGLGL

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP001358
EMBL· GenBank· DDBJ
ACL50183.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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