B8I6E1 · ISPG_RUMCH

Function

function

Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.

Catalytic activity

Cofactor

[4Fe-4S] cluster (UniProtKB | Rhea| CHEBI:49883 )

Note: Binds 1 [4Fe-4S] cluster.

Pathway

Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 5/6.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site268[4Fe-4S] cluster (UniProtKB | ChEBI)
Binding site271[4Fe-4S] cluster (UniProtKB | ChEBI)
Binding site303[4Fe-4S] cluster (UniProtKB | ChEBI)
Binding site310[4Fe-4S] cluster (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Function4 iron, 4 sulfur cluster binding
Molecular Function4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase activity (ferredoxin)
Molecular Function4-hydroxy-3-methylbut-2-enyl-diphosphate synthase activity (flavodoxin)
Molecular Functioniron ion binding
Biological Processisopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway
Biological Processterpenoid biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin)
  • EC number
  • Alternative names
    • 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase

Gene names

    • Name
      ispG
    • Ordered locus names
      Ccel_0451

Organism names

Accessions

  • Primary accession
    B8I6E1

Proteomes

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_10001234401-3534-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin)

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Belongs to the IspG family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    353
  • Mass (Da)
    37,931
  • Last updated
    2009-03-03 v1
  • MD5 Checksum
    98FC843B2C39AD2C28E42C50DBDE7EE7
MEDCIKRNQTKKIKVGDIFIGGDSPISVQSMTNTDTRDVKATIHQIKSLEEAGCDIVRLAILDNEAATAIGEIKKHVKIPLVADIHYDYRLAVECMKNGVDKIRLNPGNIGGNDRVRTVAGMAKERGIPIRIGVNSGSVEKRILEKFGGVTAEGMVESALAHVAMLENVDFNDIAISIKASSVPMTIAAYRLLSEKCLYPLHVGVTEAGTVYKGTIKSAVGIGCLLAEGIGDTIRVSLTGDPVEEIKVGKQILKSLDLLKEGIEIVSCPTCGRTQVNLIDIANSIEPLLEKLNKNIKVAIMGCAVNGPGEAKDADIGIAGGVNEVLLFKKGRIIRKIPQENVVEELIKEISEM

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP001348
EMBL· GenBank· DDBJ
ACL74833.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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