B8H8V5 · AROB_PSECP
- Protein3-dehydroquinate synthase
- GenearoB
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids363 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).
Catalytic activity
- 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate = 3-dehydroquinate + phosphate
Cofactor
Protein has several cofactor binding sites:
Zn2+ (UniProtKB | Rhea| CHEBI:29105 )
Note: Binds 1 divalent metal cation per subunit. Can use either Co2+ or Zn2+.
Pathway
Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 2/7.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 75-80 | NAD+ (UniProtKB | ChEBI) | |||
Binding site | 109-113 | NAD+ (UniProtKB | ChEBI) | |||
Binding site | 133-134 | NAD+ (UniProtKB | ChEBI) | |||
Binding site | 146 | NAD+ (UniProtKB | ChEBI) | |||
Binding site | 155 | NAD+ (UniProtKB | ChEBI) | |||
Binding site | 173-176 | NAD+ (UniProtKB | ChEBI) | |||
Binding site | 188 | Zn2+ (UniProtKB | ChEBI) | |||
Binding site | 251 | Zn2+ (UniProtKB | ChEBI) | |||
Binding site | 267 | Zn2+ (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | 3-dehydroquinate synthase activity | |
Molecular Function | metal ion binding | |
Molecular Function | nucleotide binding | |
Biological Process | amino acid biosynthetic process | |
Biological Process | aromatic amino acid family biosynthetic process | |
Biological Process | chorismate biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended name3-dehydroquinate synthase
- EC number
- Short namesDHQS
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Actinomycetota > Actinomycetes > Micrococcales > Micrococcaceae > Pseudarthrobacter
Accessions
- Primary accessionB8H8V5
Proteomes
Subcellular Location
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_1000119070 | 1-363 | 3-dehydroquinate synthase | ||
Interaction
Protein-protein interaction databases
Structure
Sequence
- Sequence statusComplete
- Length363
- Mass (Da)38,969
- Last updated2009-03-03 v1
- MD5 ChecksumEBE22A3CBDDF44FB3742D78D2BC7D3C3
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP001341 EMBL· GenBank· DDBJ | ACL39983.1 EMBL· GenBank· DDBJ | Genomic DNA |