B8EIE0 · B8EIE0_METSB
- ProteinUDP-glucose 6-dehydrogenase
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids439 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
Catalytic activity
- UDP-alpha-D-glucose + 2 NAD+ + H2O = UDP-alpha-D-glucuronate + 2 NADH + 3 H+
Pathway
Nucleotide-sugar biosynthesis; UDP-alpha-D-glucuronate biosynthesis; UDP-alpha-D-glucuronate from UDP-alpha-D-glucose: step 1/1.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 30 | NAD+ (UniProtKB | ChEBI) | |||
Binding site | 35 | NAD+ (UniProtKB | ChEBI) | |||
Binding site | 86 | NAD+ (UniProtKB | ChEBI) | |||
Binding site | 122 | NAD+ (UniProtKB | ChEBI) | |||
Binding site | 152-155 | substrate | |||
Binding site | 155 | NAD+ (UniProtKB | ChEBI) | |||
Binding site | 207 | substrate | |||
Binding site | 252-256 | substrate | |||
Binding site | 260 | substrate | |||
Active site | 263 | Nucleophile | |||
Binding site | 266 | NAD+ (UniProtKB | ChEBI) | |||
Binding site | 324 | substrate | |||
Binding site | 331 | NAD+ (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | NAD binding | |
Molecular Function | UDP-glucose 6-dehydrogenase activity | |
Biological Process | polysaccharide biosynthetic process | |
Biological Process | UDP-glucuronate biosynthetic process |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameUDP-glucose 6-dehydrogenase
- EC number
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Alphaproteobacteria > Hyphomicrobiales > Beijerinckiaceae > Methylocella
Accessions
- Primary accessionB8EIE0
Proteomes
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 317-418 | UDP-glucose/GDP-mannose dehydrogenase C-terminal | |||
Sequence similarities
Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length439
- Mass (Da)47,963
- Last updated2009-03-03 v1
- ChecksumBAA8F947F5846C44
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP001280 EMBL· GenBank· DDBJ | ACK51259.1 EMBL· GenBank· DDBJ | Genomic DNA |