B8EI85 · B8EI85_METSB
- Proteinthioredoxin-dependent peroxiredoxin
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids161 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events.
Catalytic activity
- a hydroperoxide + [thioredoxin]-dithiol = an alcohol + [thioredoxin]-disulfide + H2O
CHEBI:35924 + RHEA-COMP:10698 CHEBI:29950 Position: nCHEBI:29950 Position: n+3= CHEBI:30879 + RHEA-COMP:10700 CHEBI:50058 Position: n/n+3+ CHEBI:15377
Features
Showing features for active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Active site | 51 | Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | thioredoxin peroxidase activity | |
Biological Process | cell redox homeostasis | |
Biological Process | cellular response to oxidative stress |
Keywords
- Molecular function
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namethioredoxin-dependent peroxiredoxin
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Alphaproteobacteria > Hyphomicrobiales > Beijerinckiaceae > Methylocella
Accessions
- Primary accessionB8EI85
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Interaction
Structure
Family & Domains
Features
Showing features for region, domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Region | 1-23 | Disordered | |||
Domain | 9-161 | Thioredoxin | |||
Sequence similarities
Belongs to the peroxiredoxin family. BCP/PrxQ subfamily.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length161
- Mass (Da)17,428
- Last updated2009-03-03 v1
- Checksum44FFE9F04A8B0905
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP001280 EMBL· GenBank· DDBJ | ACK50567.1 EMBL· GenBank· DDBJ | Genomic DNA |