B8DH77 · COAD_LISMH
- ProteinPhosphopantetheine adenylyltransferase
- GenecoaD
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids160 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.
Catalytic activity
- (R)-4'-phosphopantetheine + ATP + H+ = 3'-dephospho-CoA + diphosphate
Cofactor
Pathway
Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 4/5.
Features
Showing features for binding site, site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 11 | substrate | |||
Binding site | 11-12 | ATP (UniProtKB | ChEBI) | |||
Binding site | 19 | ATP (UniProtKB | ChEBI) | |||
Site | 19 | Transition state stabilizer | |||
Binding site | 43 | substrate | |||
Binding site | 75 | substrate | |||
Binding site | 89 | substrate | |||
Binding site | 90-92 | ATP (UniProtKB | ChEBI) | |||
Binding site | 100 | ATP (UniProtKB | ChEBI) | |||
Binding site | 125-131 | ATP (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | ATP binding | |
Molecular Function | pantetheine-phosphate adenylyltransferase activity | |
Biological Process | coenzyme A biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namePhosphopantetheine adenylyltransferase
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Bacillota > Bacilli > Bacillales > Listeriaceae > Listeria
Accessions
- Primary accessionB8DH77
Subcellular Location
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_1000123290 | 1-160 | Phosphopantetheine adenylyltransferase | ||
Interaction
Subunit
Homohexamer.
Structure
Sequence
- Sequence statusComplete
- Length160
- Mass (Da)17,770
- Last updated2009-03-03 v1
- Checksum05C6867839AA2DD4
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP001175 EMBL· GenBank· DDBJ | ACK38865.1 EMBL· GenBank· DDBJ | Genomic DNA |