B8BQ53 · B8BQ53_THAPS
- ProteinInosine triphosphate pyrophosphatase
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids203 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) or xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions.
Catalytic activity
- ITP + H2O = IMP + diphosphate + H+
Cofactor
Mn2+ (UniProtKB | Rhea| CHEBI:29035 )
Note: Binds 1 divalent metal cation per subunit; can use either Mg2+ or Mn2+.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 10-15 | ITP (UniProtKB | ChEBI) | |||
Binding site | 51 | Mg2+ (UniProtKB | ChEBI) | |||
Binding site | 63 | ITP (UniProtKB | ChEBI) | |||
Binding site | 79 | Mg2+ (UniProtKB | ChEBI) | |||
Binding site | 79-80 | ITP (UniProtKB | ChEBI) | |||
Binding site | 156-159 | ITP (UniProtKB | ChEBI) | |||
Binding site | 180 | ITP (UniProtKB | ChEBI) | |||
Binding site | 185-186 | ITP (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | 8-oxo-(d)RTP hydrolase activity | |
Molecular Function | dITP diphosphatase activity | |
Molecular Function | ITP diphosphatase activity | |
Molecular Function | metal ion binding | |
Molecular Function | nucleoside triphosphate diphosphatase activity | |
Molecular Function | nucleotide binding | |
Molecular Function | XTP diphosphatase activity | |
Biological Process | deoxyribonucleoside triphosphate catabolic process | |
Biological Process | nucleoside triphosphate catabolic process | |
Biological Process | nucleotide metabolic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameInosine triphosphate pyrophosphatase
- EC number
- Short namesITPase ; Inosine triphosphatase
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Sar > Stramenopiles > Ochrophyta > Bacillariophyta > Coscinodiscophyceae > Thalassiosirophycidae > Thalassiosirales > Thalassiosiraceae > Thalassiosira
Accessions
- Primary accessionB8BQ53
Proteomes
Subcellular Location
PTM/Processing
Proteomic databases
Interaction
Structure
Sequence
- Sequence statusComplete
- Length203
- Mass (Da)22,686
- Last updated2009-03-03 v1
- MD5 Checksum7920F3123D41EB1E0E82F0FB15497FA6
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CM000638 EMBL· GenBank· DDBJ | EED95726.1 EMBL· GenBank· DDBJ | Genomic DNA |