B8A5I7 · SSBP_DANRE
- ProteinSingle-stranded DNA-binding protein, mitochondrial
- Genessbp1
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids146 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score3/5
Function
function
Binds preferentially and cooperatively to pyrimidine rich single-stranded DNA (ss-DNA) (By similarity).
May be required to maintain the copy number of mitochondrial DNA (mtDNA) and play a crucial role during mtDNA replication (PubMed:31550240).
Required for retinal ganglion cell differentiation and retinal integrity (PubMed:31298765).
May be required to maintain the copy number of mitochondrial DNA (mtDNA) and play a crucial role during mtDNA replication (PubMed:31550240).
Required for retinal ganglion cell differentiation and retinal integrity (PubMed:31298765).
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | mitochondrial nucleoid | |
Molecular Function | single-stranded DNA binding | |
Biological Process | mitochondrial DNA replication |
Keywords
- Molecular function
- Biological process
Names & Taxonomy
Protein names
- Recommended nameSingle-stranded DNA-binding protein, mitochondrial
- Short namesMt-SSB ; MtSSB
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Cypriniformes > Danionidae > Danioninae > Danio
Accessions
- Primary accessionB8A5I7
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Keywords
- Cellular component
Phenotypes & Variants
Disruption phenotype
Morpholino-induced knockdown results in reduction in optic nerve size and mitochondrial depletion (PubMed:31298765, PubMed:31550240).
Strongly reduced expression of the developmental regulator genes isl1 and atoh7 in retinal ganglion cell (RGC) precursors (PubMed:31298765).
Nonphotoreceptor cells, both in the ganglion cell layer and in the inner nuclear layer, display compromised neuronal specification, whereas cell numbers in both layers are unaltered (PubMed:31298765).
Strongly reduced expression of the developmental regulator genes isl1 and atoh7 in retinal ganglion cell (RGC) precursors (PubMed:31298765).
Nonphotoreceptor cells, both in the ganglion cell layer and in the inner nuclear layer, display compromised neuronal specification, whereas cell numbers in both layers are unaltered (PubMed:31298765).
Features
Showing features for mutagenesis.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Mutagenesis | 37 | Reduction in retinal atoh7 expression. | ||||
Sequence: R → Q | ||||||
Mutagenesis | 106 | Reduction in retinal atoh7 expression. | ||||
Sequence: R → Q | ||||||
Mutagenesis | 140 | Reduction in retinal atoh7 expression. | ||||
Sequence: S → N |
PTM/Processing
Features
Showing features for transit peptide, chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transit peptide | 1-16 | Mitochondrion | ||||
Sequence: MLRNASAQILKQFVRH | ||||||
Chain | PRO_0000453180 | 17-146 | Single-stranded DNA-binding protein, mitochondrial | |||
Sequence: RTTDASLTLEKSINKVQILGRVGQDPVMRQVEGRNPVTIFSMATNEMWRSGEGEPVGAGDVTQKTTWHRISVFKPGLRDVAYQYVKKGSRIFVEGKLDYGEYVDKNNVRRQATTIIADNIVFLSENLRDQ |
Proteomic databases
Expression
Gene expression databases
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 29-140 | SSB | ||||
Sequence: INKVQILGRVGQDPVMRQVEGRNPVTIFSMATNEMWRSGEGEPVGAGDVTQKTTWHRISVFKPGLRDVAYQYVKKGSRIFVEGKLDYGEYVDKNNVRRQATTIIADNIVFLS |
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
- Length146
- Mass (Da)16,598
- Last updated2009-03-03 v1
- ChecksumA171D3A8CDA9F273
Features
Showing features for sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Sequence conflict | 4 | in Ref. 2; AAH92875/AAI64281 | ||||
Sequence: N → Y | ||||||
Sequence conflict | 16 | in Ref. 2; AAH92875/AAI64281 | ||||
Sequence: H → Q |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
BX546489 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
BC092875 EMBL· GenBank· DDBJ | AAH92875.1 EMBL· GenBank· DDBJ | mRNA | ||
BC164281 EMBL· GenBank· DDBJ | AAI64281.1 EMBL· GenBank· DDBJ | mRNA |