B7ZMZ2 · B7ZMZ2_MOUSE
- ProteinTyrosine-protein kinase
- GeneAbl2
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids1078 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score3/5
Function
Catalytic activity
- L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H+
Features
Showing features for binding site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | ATP binding | |
Molecular Function | non-membrane spanning protein tyrosine kinase activity | |
Biological Process | cell communication | |
Biological Process | protein phosphorylation | |
Biological Process | regulation of cellular component organization | |
Biological Process | signaling |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameTyrosine-protein kinase
- EC number
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionB7ZMZ2
Organism-specific databases
Subcellular Location
PTM/Processing
Proteomic databases
Structure
Family & Domains
Features
Showing features for region, domain, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-42 | Disordered | ||||
Sequence: MGQQVGRVGEAPGLQQPQPRGIRGSSAARPSGRRRDPAGRTA | ||||||
Domain | 107-167 | SH3 | ||||
Sequence: SDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNGQGWVPSNYITPVNS | ||||||
Domain | 173-263 | SH2 | ||||
Sequence: WYHGPISRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTTTDSKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPA | ||||||
Domain | 288-539 | Protein kinase | ||||
Sequence: ITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECSREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSFAETHQAF | ||||||
Region | 612-642 | Disordered | ||||
Sequence: IRSTQASSGSPALPRKQRDKSPSSLLEDAKE | ||||||
Region | 655-680 | Disordered | ||||
Sequence: SSFMKKRNAPTPPKRSSSFREMENQP | ||||||
Compositional bias | 708-724 | Polar residues | ||||
Sequence: LQLERTVSTSSQPEENV | ||||||
Region | 708-775 | Disordered | ||||
Sequence: LQLERTVSTSSQPEENVDRANDMLPKKSEEGAAPARERPKAKLLPRGATALPLRAPDPAITESDSPGV | ||||||
Compositional bias | 726-750 | Basic and acidic residues | ||||
Sequence: RANDMLPKKSEEGAAPARERPKAKL | ||||||
Region | 860-951 | Disordered | ||||
Sequence: HQVTSSGDKDRPRRVKPKCAPPPPPVMRLLQHPSTCSDPEEEPTAPPAGQHTPETQEGGKKAAPGPMPSSGKPGRPVMPPPQVPLPTSSISP | ||||||
Compositional bias | 862-876 | Basic and acidic residues | ||||
Sequence: VTSSGDKDRPRRVKP | ||||||
Compositional bias | 928-946 | Pro residues | ||||
Sequence: SSGKPGRPVMPPPQVPLPT |
Sequence similarities
Belongs to the protein kinase superfamily. Tyr protein kinase family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,078
- Mass (Da)117,780
- Last updated2009-03-03 v1
- ChecksumA655898647DA295E
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 708-724 | Polar residues | ||||
Sequence: LQLERTVSTSSQPEENV | ||||||
Compositional bias | 726-750 | Basic and acidic residues | ||||
Sequence: RANDMLPKKSEEGAAPARERPKAKL | ||||||
Compositional bias | 862-876 | Basic and acidic residues | ||||
Sequence: VTSSGDKDRPRRVKP | ||||||
Compositional bias | 928-946 | Pro residues | ||||
Sequence: SSGKPGRPVMPPPQVPLPT |