B7ZMF5 · B7ZMF5_HUMAN
- ProteinCalcium-activated potassium channel subunit alpha-1
- GeneKCNMA1
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids1208 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score3/5
Function
Catalytic activity
- K+(in) = K+(out)
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Aspect | Term | |
---|---|---|
Cellular Component | membrane | |
Molecular Function | ligand-gated monoatomic cation channel activity | |
Molecular Function | monoatomic ion-gated channel activity | |
Molecular Function | potassium channel activity |
Keywords
- Molecular function
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameCalcium-activated potassium channel subunit alpha-1
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionB7ZMF5
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 86-108 | Helical | ||||
Sequence: MWWAFLASSMVTFFGGLFIILLW | ||||||
Transmembrane | 179-197 | Helical | ||||
Sequence: VLVVLVFALSIGALVIYFI | ||||||
Transmembrane | 217-235 | Helical | ||||
Sequence: IDMAFNVFFLLYFGLRFIA | ||||||
Transmembrane | 300-321 | Helical | ||||
Sequence: LVNLLSIFISTWLTAAGFIHLV | ||||||
Transmembrane | 336-355 | Helical | ||||
Sequence: ALTYWECVYLLMVTMSTVGY | ||||||
Transmembrane | 367-385 | Helical | ||||
Sequence: LFMVFFILGGLAMFASYVP |
Keywords
- Cellular component
Disease & Variants
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 1,215 variants from UniProt as well as other sources including ClinVar and dbSNP.
Organism-specific databases
Genetic variation databases
PTM/Processing
Features
Showing features for modified residue (large scale data).
Type | ID | Position(s) | Source | Description | |||
---|---|---|---|---|---|---|---|
Modified residue (large scale data) | 710 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 1060 | PRIDE | Phosphothreonine | ||||
Sequence: T | |||||||
Modified residue (large scale data) | 1177 | PRIDE | Phosphoserine | ||||
Sequence: S |
Keywords
- PTM
Expression
Gene expression databases
Structure
Family & Domains
Features
Showing features for region, compositional bias, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-61 | Disordered | ||||
Sequence: MANGGGGGGGSSGGGGGGGGSSLRMSSNIHANHLSLDASSSSSSSSSSSSSSSSSSSSSSV | ||||||
Compositional bias | 21-61 | Polar residues | ||||
Sequence: SSLRMSSNIHANHLSLDASSSSSSSSSSSSSSSSSSSSSSV | ||||||
Domain | 181-396 | Ion transport | ||||
Sequence: VVLVFALSIGALVIYFIDSSNPIESCQNFYKDFTLQIDMAFNVFFLLYFGLRFIAANDKLWFWLEVNSVVDFFTVPPVFVSVYLNRSWLGLRFLRALRLIQFSEILQFLNILKTSNSIKLVNLLSIFISTWLTAAGFIHLVENSGDPWENFQNNQALTYWECVYLLMVTMSTVGYGDVYAKTTLGRLFMVFFILGGLAMFASYVPEIIELIGNRKK | ||||||
Domain | 546-633 | Calcium-activated potassium channel BK alpha subunit | ||||
Sequence: DDAICLAELKLGFIAQSCLAQGLSTMLANLFSMRSFIKIEEDTWQKYYLEGVSNEMYTEYLSSAFVGLSFPTVCELCFVKLKLLMIAI | ||||||
Region | 707-732 | Disordered | ||||
Sequence: STLSPKKKQRNGGMRNSPNTSPKLMR | ||||||
Compositional bias | 711-729 | Polar residues | ||||
Sequence: PKKKQRNGGMRNSPNTSPK | ||||||
Domain | 1028-1148 | Ca2+-activated K+ channel Slowpoke-like C-terminal | ||||
Sequence: ILTLIRTLVTGGATPELEALIAEENALRGGYSTPQTLANRDRCRVAQLALLDGPFADLGDGGCYGDLFCKALKTYNMLCFGIYRLRDAHLSTPSQCTKRYVITNPPYEFELVPTDLIFCLM | ||||||
Compositional bias | 1158-1189 | Polar residues | ||||
Sequence: RASLSHSSHSSQSSSKKSSSVHSIPSTANRQN | ||||||
Region | 1158-1208 | Disordered | ||||
Sequence: RASLSHSSHSSQSSSKKSSSVHSIPSTANRQNRPKSRESRDKQKYVQEERL | ||||||
Compositional bias | 1190-1208 | Basic and acidic residues | ||||
Sequence: RPKSRESRDKQKYVQEERL |
Sequence similarities
Belongs to the potassium channel family. Calcium-activated (TC 1.A.1.3) subfamily. KCa1.1/KCNMA1 sub-subfamily.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,208
- Mass (Da)134,323
- Last updated2009-03-03 v1
- ChecksumCFEBB7F88FBB1B9E
Computationally mapped potential isoform sequences
There are 70 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
Q12791 | KCMA1_HUMAN | KCNMA1 | 1236 | ||
J3KQ16 | J3KQ16_HUMAN | KCNMA1 | 1040 | ||
D5MRH1 | D5MRH1_HUMAN | KCNMA1 | 1128 | ||
A0A1B0GWD4 | A0A1B0GWD4_HUMAN | KCNMA1 | 459 | ||
A0A1W2PP76 | A0A1W2PP76_HUMAN | KCNMA1 | 30 | ||
A0A1W2PP94 | A0A1W2PP94_HUMAN | KCNMA1 | 1181 | ||
A0A1W2PP06 | A0A1W2PP06_HUMAN | KCNMA1 | 1223 | ||
A0A1W2PP26 | A0A1W2PP26_HUMAN | KCNMA1 | 1198 | ||
A0A1W2PP37 | A0A1W2PP37_HUMAN | KCNMA1 | 99 | ||
Q5SVJ7 | Q5SVJ7_HUMAN | KCNMA1 | 1209 | ||
Q5SVJ8 | Q5SVJ8_HUMAN | KCNMA1 | 1288 | ||
Q5SVJ9 | Q5SVJ9_HUMAN | KCNMA1 | 1235 | ||
Q5SVK0 | Q5SVK0_HUMAN | KCNMA1 | 1195 | ||
Q5SVK5 | Q5SVK5_HUMAN | KCNMA1 | 1232 | ||
A0A1W2PPX7 | A0A1W2PPX7_HUMAN | KCNMA1 | 1242 | ||
A0A1W2PPY5 | A0A1W2PPY5_HUMAN | KCNMA1 | 1230 | ||
A0A1W2PPZ1 | A0A1W2PPZ1_HUMAN | KCNMA1 | 1238 | ||
A0A1W2PQ93 | A0A1W2PQ93_HUMAN | KCNMA1 | 1197 | ||
A0A1W2PPQ3 | A0A1W2PPQ3_HUMAN | KCNMA1 | 1178 | ||
A0A1W2PPS2 | A0A1W2PPS2_HUMAN | KCNMA1 | 1122 | ||
A0A1W2PQ39 | A0A1W2PQ39_HUMAN | KCNMA1 | 583 | ||
A0A1W2PPT7 | A0A1W2PPT7_HUMAN | KCNMA1 | 422 | ||
A0A1W2PQ53 | A0A1W2PQ53_HUMAN | KCNMA1 | 1115 | ||
A0A1W2PQ61 | A0A1W2PQ61_HUMAN | KCNMA1 | 1181 | ||
A0A1W2PPH9 | A0A1W2PPH9_HUMAN | KCNMA1 | 1175 | ||
A0A1W2PNW6 | A0A1W2PNW6_HUMAN | KCNMA1 | 1230 | ||
A0A1W2PNX9 | A0A1W2PNX9_HUMAN | KCNMA1 | 575 | ||
A0A1W2PNY7 | A0A1W2PNY7_HUMAN | KCNMA1 | 1161 | ||
A0A1W2PNY8 | A0A1W2PNY8_HUMAN | KCNMA1 | 1020 | ||
A0A1W2PNY9 | A0A1W2PNY9_HUMAN | KCNMA1 | 1233 | ||
A0A1W2PNN5 | A0A1W2PNN5_HUMAN | KCNMA1 | 154 | ||
A0A1W2PNN6 | A0A1W2PNN6_HUMAN | KCNMA1 | 100 | ||
A0A1W2PNQ3 | A0A1W2PNQ3_HUMAN | KCNMA1 | 1177 | ||
H0Y379 | H0Y379_HUMAN | KCNMA1 | 1192 | ||
H0Y382 | H0Y382_HUMAN | KCNMA1 | 1182 | ||
A0A1W2PNG1 | A0A1W2PNG1_HUMAN | KCNMA1 | 1146 | ||
H0Y406 | H0Y406_HUMAN | KCNMA1 | 208 | ||
A0A1W2PNH9 | A0A1W2PNH9_HUMAN | KCNMA1 | 1181 | ||
A0A1W2PSD3 | A0A1W2PSD3_HUMAN | KCNMA1 | 1178 | ||
A0A1W2PQZ4 | A0A1W2PQZ4_HUMAN | KCNMA1 | 357 | ||
A0A1W2PQZ8 | A0A1W2PQZ8_HUMAN | KCNMA1 | 403 | ||
A0A1W2PRA7 | A0A1W2PRA7_HUMAN | KCNMA1 | 964 | ||
A0A1W2PQR1 | A0A1W2PQR1_HUMAN | KCNMA1 | 584 | ||
A0A1W2PR56 | A0A1W2PR56_HUMAN | KCNMA1 | 1212 | ||
A0A1W2PQU4 | A0A1W2PQU4_HUMAN | KCNMA1 | 1178 | ||
A0A1W2PR62 | A0A1W2PR62_HUMAN | KCNMA1 | 1236 | ||
A0A1W2PQJ9 | A0A1W2PQJ9_HUMAN | KCNMA1 | 1119 | ||
A0A1W2PQK5 | A0A1W2PQK5_HUMAN | KCNMA1 | 1177 | ||
A0A1W2PQA0 | A0A1W2PQA0_HUMAN | KCNMA1 | 1234 | ||
A0A1W2PSA7 | A0A1W2PSA7_HUMAN | KCNMA1 | 78 | ||
A0A1W2PRT6 | A0A1W2PRT6_HUMAN | KCNMA1 | 383 | ||
A0A1W2PS54 | A0A1W2PS54_HUMAN | KCNMA1 | 190 | ||
A0A1W2PRJ1 | A0A1W2PRJ1_HUMAN | KCNMA1 | 977 | ||
A0A1W2PRV4 | A0A1W2PRV4_HUMAN | KCNMA1 | 1246 | ||
A0A1W2PRX6 | A0A1W2PRX6_HUMAN | KCNMA1 | 1196 | ||
A0A1W2PS97 | A0A1W2PS97_HUMAN | KCNMA1 | 1142 | ||
A0A1W2PRN5 | A0A1W2PRN5_HUMAN | KCNMA1 | 1239 | ||
A0A1W2PRB0 | A0A1W2PRB0_HUMAN | KCNMA1 | 1234 | ||
A0A1W2PRC3 | A0A1W2PRC3_HUMAN | KCNMA1 | 97 | ||
A0A1W2PRE5 | A0A1W2PRE5_HUMAN | KCNMA1 | 1185 | ||
A0A1W2PRF1 | A0A1W2PRF1_HUMAN | KCNMA1 | 91 | ||
A0A1W2PRG5 | A0A1W2PRG5_HUMAN | KCNMA1 | 1208 | ||
A0A0A0MRR0 | A0A0A0MRR0_HUMAN | KCNMA1 | 1233 | ||
A0A9L9PYL6 | A0A9L9PYL6_HUMAN | KCNMA1 | 512 | ||
A0A0A0MSE6 | A0A0A0MSE6_HUMAN | KCNMA1 | 1142 | ||
A0A9L9PXP1 | A0A9L9PXP1_HUMAN | KCNMA1 | 1084 | ||
A0A0A0MRC3 | A0A0A0MRC3_HUMAN | KCNMA1 | 1071 | ||
S4R453 | S4R453_HUMAN | KCNMA1 | 128 | ||
S4R2X4 | S4R2X4_HUMAN | KCNMA1 | 1043 | ||
A0A087WZL8 | A0A087WZL8_HUMAN | KCNMA1 | 213 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 21-61 | Polar residues | ||||
Sequence: SSLRMSSNIHANHLSLDASSSSSSSSSSSSSSSSSSSSSSV | ||||||
Compositional bias | 711-729 | Polar residues | ||||
Sequence: PKKKQRNGGMRNSPNTSPK | ||||||
Compositional bias | 1158-1189 | Polar residues | ||||
Sequence: RASLSHSSHSSQSSSKKSSSVHSIPSTANRQN | ||||||
Compositional bias | 1190-1208 | Basic and acidic residues | ||||
Sequence: RPKSRESRDKQKYVQEERL |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AC011439 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AC021032 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AC067745 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AL157833 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AL607069 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AL627447 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AL731556 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AL731560 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AL731575 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
BC144496 EMBL· GenBank· DDBJ | AAI44497.1 EMBL· GenBank· DDBJ | mRNA |