B7ZLD0 · B7ZLD0_HUMAN
- ProteinLow-density lipoprotein receptor-related protein
- GeneLRP6
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids1568 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score3/5
Function
function
Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalosomes.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | plasma membrane | |
Cellular Component | synapse | |
Molecular Function | Wnt receptor activity | |
Molecular Function | Wnt-protein binding | |
Biological Process | canonical Wnt signaling pathway | |
Biological Process | chemical synaptic transmission | |
Biological Process | receptor-mediated endocytosis involved in cholesterol transport | |
Biological Process | Wnt signaling pathway involved in somitogenesis |
Keywords
- Molecular function
- Biological process
Names & Taxonomy
Protein names
- Recommended nameLow-density lipoprotein receptor-related protein
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionB7ZLD0
Subcellular Location
UniProt Annotation
GO Annotation
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 1329-1349 | Helical | ||||
Sequence: VGSVIGVIVTIFVSGTVYFIC |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for signal, chain, disulfide bond.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-19 | |||||
Sequence: MGAVLRSLLACSFCVLLRA | ||||||
Chain | PRO_5010897968 | 20-1568 | Low-density lipoprotein receptor-related protein | |||
Sequence: APLLLYANRRDLRLVDATNGKENATIVVGGLEDAAAVDFVFSHGLIYWSDVSEEAIKRTEFNKTESVQNVVVSGLLSPDGLACDWLGEKLYWTDSETNRIEVSNLDGSLRKVLFWQELDQPRAIALDPSSGFMYWTDWGEVPKIERAGMDGSSRFIIINSEIYWPNGLTLDYEEQKLYWADAKLNFIHKSNLDGTNRQAVVKGSLPHPFALTLFEDILYWTDWSTHSILACNKYTGEGLREIHSDIFSPMDIHAFSQQRQPNATNPCGIDNGGCSHLCLMSPVKPFYQCACPTGVKLLENGKTCKDGATELLLLARRTDLRRISLDTPDFTDIVLQLEDIRHAIAIDYDPVEGYIYWTDDEVRAIRRSFIDGSGSQFVVTAQIAHPDGIAVDWVARNLYWTDTGTDRIEVTRLNGTMRKILISEDLEEPRAIVLDPMVGYMYWTDWGEIPKIERAALDGSDRVVLVNTSLGWPNGLALDYDEGKIYWGDAKTDKIEVMNTDGTGRRVLVEDKIPHIFGFTLLGDYVYWTDWQRRSIERVHKRSAEREVIIDQLPDLMGLKATNVHRVIGSNPCAEENGGCSHLCLYRPQGLRCACPIGFELISDMKTCIVPEAFLLFSRRADIRRISLETNNNNVAIPLTGVKEASALDFDVTDNRIYWTDISLKTISRAFMNGSALEHVVEFGLDYPEGMAVDWLGKNLYWADTGTNRIEVSKLDGQHRQVLVWKDLDSPRALALDPAEGFMYWTEWGGKPKIDRAAMDGSERTTLVPNVGRANGLTIDYAKRRLYWTDLDTNLIESSNMLGLNREVIADDLPHPFGLTQYQDYIYWTDWSRRSIERANKTSGQNRTIIQGHLDYVMDILVFHSSRQSGWNECASSNGHCSHLCLAVPVGGFVCGCPAHYSLNADNRTCSAPTTFLLFSQKSAINRMVIDEQQSPDIILPIHSLRNVRAIDYDPLDKQLYWIDSRQNMIRKAQEDGSQGFTVVVSSVPSQNLEIQPYDLSIDIYSRYIYWTCEATNVINVTRLDGRSVGVVLKGEQDRPRAIVVNPEKGYMYFTNLQERSPKIERAALDGTEREVLFFSGLSKPIALALDSRLGKLFWADSDLRRIESSDLSGANRIVLEDSNILQPVGLTVFENWLYWIDKQQQMIEKIDMTGREGRTKVQARIAQLSDIHAVKELNLQEYRQHPCAQDNGGCSHICLVKGDGTTRCSCPMHLVLLQDELSCGESQFQCASGQCIDGALRCNGDANCQDKSDEKNCEVLCLIDQFRCANGQCIGKHKKCDHNVDCSDKSDELDCYPTEEPAPQATNTVGSVIGVIVTIFVSGTVYFICQRMLCPRMKGDGETMTNDYVVHGPASVPLGYVPHPSSLSGSLPGMSRGKSMISSLSIMGGSSGPPYDRAHVTGASSSSSSSTKGTYFPAILNPPPSPATERSHYTMEFGYSSNSPSTHRSYSYRPYSYRHFAPPTTPCSTDVCDSDYAPSRRMTSVATAKGYTSDLNYDSEPVPPPPTPRSQYLSAEENYESCPPSPYTERSYSHHLYPPPPSPCTDSS | ||||||
Disulfide bond | 1243↔1255 | |||||
Sequence: CGESQFQCASGQC | ||||||
Disulfide bond | 1250↔1268 | |||||
Sequence: CASGQCIDGALRCNGDANC | ||||||
Disulfide bond | 1262↔1277 | |||||
Sequence: CNGDANCQDKSDEKNC | ||||||
Disulfide bond | 1281↔1293 | |||||
Sequence: CLIDQFRCANGQC | ||||||
Disulfide bond | 1288↔1306 | |||||
Sequence: CANGQCIGKHKKCDHNVDC | ||||||
Disulfide bond | 1300↔1315 | |||||
Sequence: CDHNVDCSDKSDELDC |
Keywords
- PTM
Proteomic databases
Interaction
Subunit
Homodimer; disulfide-linked. Forms phosphorylated oligomer aggregates on Wnt-signaling.
Family & Domains
Features
Showing features for repeat, domain, region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Repeat | 63-106 | LDL-receptor class B | ||||
Sequence: GLIYWSDVSEEAIKRTEFNKTESVQNVVVSGLLSPDGLACDWLG | ||||||
Repeat | 107-149 | LDL-receptor class B | ||||
Sequence: EKLYWTDSETNRIEVSNLDGSLRKVLFWQELDQPRAIALDPSS | ||||||
Repeat | 150-193 | LDL-receptor class B | ||||
Sequence: GFMYWTDWGEVPKIERAGMDGSSRFIIINSEIYWPNGLTLDYEE | ||||||
Repeat | 194-236 | LDL-receptor class B | ||||
Sequence: QKLYWADAKLNFIHKSNLDGTNRQAVVKGSLPHPFALTLFEDI | ||||||
Domain | 285-324 | EGF-like | ||||
Sequence: PCGIDNGGCSHLCLMSPVKPFYQCACPTGVKLLENGKTCK | ||||||
Repeat | 372-414 | LDL-receptor class B | ||||
Sequence: GYIYWTDDEVRAIRRSFIDGSGSQFVVTAQIAHPDGIAVDWVA | ||||||
Repeat | 415-457 | LDL-receptor class B | ||||
Sequence: RNLYWTDTGTDRIEVTRLNGTMRKILISEDLEEPRAIVLDPMV | ||||||
Repeat | 458-501 | LDL-receptor class B | ||||
Sequence: GYMYWTDWGEIPKIERAALDGSDRVVLVNTSLGWPNGLALDYDE | ||||||
Repeat | 502-544 | LDL-receptor class B | ||||
Sequence: GKIYWGDAKTDKIEVMNTDGTGRRVLVEDKIPHIFGFTLLGDY | ||||||
Domain | 591-628 | EGF-like | ||||
Sequence: PCAEENGGCSHLCLYRPQGLRCACPIGFELISDMKTCI | ||||||
Repeat | 674-716 | LDL-receptor class B | ||||
Sequence: NRIYWTDISLKTISRAFMNGSALEHVVEFGLDYPEGMAVDWLG | ||||||
Repeat | 717-759 | LDL-receptor class B | ||||
Sequence: KNLYWADTGTNRIEVSKLDGQHRQVLVWKDLDSPRALALDPAE | ||||||
Repeat | 760-802 | LDL-receptor class B | ||||
Sequence: GFMYWTEWGGKPKIDRAAMDGSERTTLVPNVGRANGLTIDYAK | ||||||
Repeat | 843-885 | LDL-receptor class B | ||||
Sequence: DYIYWTDWSRRSIERANKTSGQNRTIIQGHLDYVMDILVFHSS | ||||||
Domain | 892-930 | EGF-like | ||||
Sequence: ECASSNGHCSHLCLAVPVGGFVCGCPAHYSLNADNRTCS | ||||||
Repeat | 1026-1068 | LDL-receptor class B | ||||
Sequence: RYIYWTCEATNVINVTRLDGRSVGVVLKGEQDRPRAIVVNPEK | ||||||
Repeat | 1069-1113 | LDL-receptor class B | ||||
Sequence: GYMYFTNLQERSPKIERAALDGTEREVLFFSGLSKPIALALDSRL | ||||||
Repeat | 1114-1156 | LDL-receptor class B | ||||
Sequence: GKLFWADSDLRRIESSDLSGANRIVLEDSNILQPVGLTVFENW | ||||||
Domain | 1206-1244 | EGF-like | ||||
Sequence: PCAQDNGGCSHICLVKGDGTTRCSCPMHLVLLQDELSCG | ||||||
Region | 1511-1568 | Disordered | ||||
Sequence: YTSDLNYDSEPVPPPPTPRSQYLSAEENYESCPPSPYTERSYSHHLYPPPPSPCTDSS |
Sequence similarities
Belongs to the LDLR family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,568
- Mass (Da)175,450
- Last updated2009-03-03 v1
- Checksum2E159CC0D275E590