B7ZAT6 · B7ZAT6_HUMAN

  • Protein
    O-acyltransferase
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Evidence at transcript level
  • Annotation score
    4/5

Function

Catalytic activity

  • (11Z)-octadecenoyl-CoA + cholesterol = cholesteryl (11Z)-octadecenoate + CoA
    This reaction proceeds in the forward direction.
  • (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + cholesterol = cholesteryl (5Z,8Z,11Z,14Z)-eicosatetraenoate + CoA
    This reaction proceeds in the forward direction.
  • (7Z)-octadecenoyl-CoA + cholesterol = cholesteryl (7Z)-octadecenoate + CoA
    This reaction proceeds in the forward direction.
  • (9Z)-hexadecenoyl-CoA + cholesterol = cholesteryl (9Z)-hexadecenoate + CoA
    This reaction proceeds in the forward direction.
  • (9Z)-octadecenoyl-CoA + cholesterol = cholesteryl (9Z-octadecenoate) + CoA
    This reaction proceeds in the forward direction.
  • (9Z,12Z)-octadecadienoyl-CoA + cholesterol = cholesteryl (9Z,12Z)-octadecadienoate + CoA
    This reaction proceeds in the forward direction.
  • a long-chain fatty acyl-CoA + a sterol = a sterol ester + CoA
    This reaction proceeds in the forward direction.
    EC:2.3.1.26 (UniProtKB | ENZYME | Rhea)
  • an acyl-CoA + cholesterol = a cholesterol ester + CoA
    This reaction proceeds in the forward direction.
  • cholesterol + hexadecanoyl-CoA = cholesteryl hexadecanoate + CoA
    This reaction proceeds in the forward direction.
  • cholesterol + octadecanoyl-CoA = cholesteryl octadecanoate + CoA
    This reaction proceeds in the forward direction.

Features

Showing features for active site.

TypeIDPosition(s)Description
Active site395

GO annotations

AspectTerm
Cellular Componentendoplasmic reticulum membrane
Molecular Functioncholesterol binding
Molecular Functioncholesterol O-acyltransferase activity
Molecular Functionfatty-acyl-CoA binding
Biological Processcholesterol efflux
Biological Processcholesterol homeostasis
Biological Processcholesterol metabolic process

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    O-acyltransferase

Organism names

  • Taxonomic identifier
  • Organism
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    B7ZAT6

Subcellular Location

Endoplasmic reticulum membrane
; Multi-pass membrane protein
Membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane76-97Helical
Transmembrane117-138Helical
Transmembrane159-179Helical
Transmembrane255-276Helical
Transmembrane296-324Helical
Transmembrane382-399Helical
Transmembrane405-424Helical
Transmembrane436-455Helical

Keywords

PTM/Processing

Keywords

Proteomic databases

Family & Domains

Sequence similarities

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    485
  • Mass (Da)
    57,198
  • Last updated
    2009-03-03 v1
  • Checksum
    7738C6BEFE1AD396
MKEVGSHFDDFVTNLIEKSASLDNGGCALTTFSVLEGEKNNHRAKDLRAPPEQGKIFIARRSLLDELLEVDHIRTIYHMFIALLILFILSTLVADYIDEGRLVLEFSLLSYAFGKFPTVVWTWWIMFLSTFSVPYFLFQHWATGYSKSSHPLIRSLFHGFLFMIFQIGVLGFGPTYVVLAYTLPPASRFIIIFEQIRFVMKAHSFVRENVPRVLNSAKEKSSTVPIPTVNQYLYFLFAPTLIYRDSYPRNPTVRWGYVAMKFAQVFGCFFYVYYIFERLCAPLFRNTKQEPFSARVLVLCVFNSILPGVLILFLTFFAFLHCWLNAFAEMLRFGDRMFYKDWWNSTSYSNYYRTWNVVVHDWLYYYAYKDFLWFFSKRFKSAAMLAVFAVSAVVHEYALAVCLSFFYPVLFVLFMFFGMAFNFIVNDSRKKPIWNVLMWTSLFLGNGVLLCFYSQEWYARQHCPLKNPTFLDYVRPRSWTCRYVF

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AK316401
EMBL· GenBank· DDBJ
BAH14772.1
EMBL· GenBank· DDBJ
mRNA

Similar Proteins

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