B7ZAT6 · B7ZAT6_HUMAN
- ProteinO-acyltransferase
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids485 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score4/5
Function
Catalytic activity
- (11Z)-octadecenoyl-CoA + cholesterol = cholesteryl (11Z)-octadecenoate + CoAThis reaction proceeds in the forward direction.
- (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + cholesterol = cholesteryl (5Z,8Z,11Z,14Z)-eicosatetraenoate + CoAThis reaction proceeds in the forward direction.
- (7Z)-octadecenoyl-CoA + cholesterol = cholesteryl (7Z)-octadecenoate + CoAThis reaction proceeds in the forward direction.
- (9Z)-hexadecenoyl-CoA + cholesterol = cholesteryl (9Z)-hexadecenoate + CoAThis reaction proceeds in the forward direction.
- (9Z)-octadecenoyl-CoA + cholesterol = cholesteryl (9Z-octadecenoate) + CoAThis reaction proceeds in the forward direction.
- (9Z,12Z)-octadecadienoyl-CoA + cholesterol = cholesteryl (9Z,12Z)-octadecadienoate + CoAThis reaction proceeds in the forward direction.
- an acyl-CoA + cholesterol = a cholesterol ester + CoAThis reaction proceeds in the forward direction.
- cholesterol + hexadecanoyl-CoA = cholesteryl hexadecanoate + CoAThis reaction proceeds in the forward direction.
- cholesterol + octadecanoyl-CoA = cholesteryl octadecanoate + CoAThis reaction proceeds in the forward direction.
Features
Showing features for active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 395 | |||||
Sequence: H |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | endoplasmic reticulum membrane | |
Molecular Function | cholesterol binding | |
Molecular Function | cholesterol O-acyltransferase activity | |
Molecular Function | fatty-acyl-CoA binding | |
Biological Process | cholesterol efflux | |
Biological Process | cholesterol homeostasis | |
Biological Process | cholesterol metabolic process |
Keywords
- Molecular function
- Biological process
Names & Taxonomy
Protein names
- Recommended nameO-acyltransferase
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionB7ZAT6
Subcellular Location
UniProt Annotation
GO Annotation
Endoplasmic reticulum membrane ; Multi-pass membrane protein
Membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 76-97 | Helical | ||||
Sequence: IYHMFIALLILFILSTLVADYI | ||||||
Transmembrane | 117-138 | Helical | ||||
Sequence: PTVVWTWWIMFLSTFSVPYFLF | ||||||
Transmembrane | 159-179 | Helical | ||||
Sequence: GFLFMIFQIGVLGFGPTYVVL | ||||||
Transmembrane | 255-276 | Helical | ||||
Sequence: WGYVAMKFAQVFGCFFYVYYIF | ||||||
Transmembrane | 296-324 | Helical | ||||
Sequence: VLVLCVFNSILPGVLILFLTFFAFLHCWL | ||||||
Transmembrane | 382-399 | Helical | ||||
Sequence: AAMLAVFAVSAVVHEYAL | ||||||
Transmembrane | 405-424 | Helical | ||||
Sequence: FFYPVLFVLFMFFGMAFNFI | ||||||
Transmembrane | 436-455 | Helical | ||||
Sequence: VLMWTSLFLGNGVLLCFYSQ |
Keywords
- Cellular component
PTM/Processing
Structure
Family & Domains
Sequence similarities
Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length485
- Mass (Da)57,198
- Last updated2009-03-03 v1
- Checksum7738C6BEFE1AD396