B7Z9R8 · B7Z9R8_HUMAN

  • Protein
    Squalene synthase
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Evidence at transcript level
  • Annotation score
    3/5

Function

function

Catalyzes the condensation of 2 farnesyl pyrophosphate (FPP) moieties to form squalene.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Pathway

Terpene metabolism; lanosterol biosynthesis; lanosterol from farnesyl diphosphate: step 1/3.

GO annotations

AspectTerm
Cellular Componentendoplasmic reticulum membrane
Molecular Functionfarnesyl-diphosphate farnesyltransferase activity
Molecular Functionfarnesyltranstransferase activity
Molecular Functionsqualene synthase activity
Biological Processcholesterol biosynthetic process
Biological Processfarnesyl diphosphate metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Squalene synthase
  • EC number
  • Short names
    SQS
    ; SS

Organism names

  • Taxonomic identifier
  • Organism
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    B7Z9R8

Subcellular Location

Disease & Variants

Organism-specific databases

PTM/Processing

Proteomic databases

Family & Domains

Sequence similarities

Belongs to the phytoene/squalene synthase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    353
  • Mass (Da)
    40,754
  • Last updated
    2009-03-03 v1
  • Checksum
    45C1DF579F179D2B
MRNAVCIFYLVLRALDTLEDDMTISVEKKVPLLHNFHSFLYQPDWRFMESKEKDRQVLEDFPTISLEFRNLAEKYQTVIADICRRMGIGMAEFLDKHVTSEQEWDKYCHYVAGLVGIGLSRLFSASEFEDPLVGEDTERANSMGLFLQKTNIIRDYLEDQQGGREFWPQEVWSRYVKKLGDFAKPENIDLAVQCLNELITNALHHIPDVITYLSRLRNQSVFNFCAIPQVMAIATLAACYNNQQVFKGAVKIRKGQAVTLMMDATNMPAVKAIIYQYMEEIYHRIPDSDPSSSKTRQIISTIRTQNLPNCQLISRSHYSPIYLSFVMPLAALSWQYLTTLSQVTEDYVQTGEH

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AK316033
EMBL· GenBank· DDBJ
BAH14404.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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