B7Z9R8 · B7Z9R8_HUMAN
- ProteinSqualene synthase
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids353 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score3/5
Function
function
Catalyzes the condensation of 2 farnesyl pyrophosphate (FPP) moieties to form squalene.
Catalytic activity
- 2 (2E,6E)-farnesyl diphosphate + H+ + NADH = 2 diphosphate + NAD+ + squalene
- 2 (2E,6E)-farnesyl diphosphate = diphosphate + presqualene diphosphateThis reaction proceeds in the forward direction.
- H+ + NADH + presqualene diphosphate = diphosphate + NAD+ + squaleneThis reaction proceeds in the forward direction.
- H+ + NADPH + presqualene diphosphate = diphosphate + NADP+ + squaleneThis reaction proceeds in the forward direction.
Cofactor
Pathway
Terpene metabolism; lanosterol biosynthesis; lanosterol from farnesyl diphosphate: step 1/3.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | endoplasmic reticulum membrane | |
Molecular Function | farnesyl-diphosphate farnesyltransferase activity | |
Molecular Function | farnesyltranstransferase activity | |
Molecular Function | squalene synthase activity | |
Biological Process | cholesterol biosynthetic process | |
Biological Process | farnesyl diphosphate metabolic process |
Keywords
- Molecular function
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameSqualene synthase
- EC number
- Short namesSQS ; SS
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionB7Z9R8
Subcellular Location
UniProt Annotation
GO Annotation
Disease & Variants
Organism-specific databases
PTM/Processing
Proteomic databases
Structure
Sequence
- Sequence statusComplete
- Length353
- Mass (Da)40,754
- Last updated2009-03-03 v1
- Checksum45C1DF579F179D2B
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AK316033 EMBL· GenBank· DDBJ | BAH14404.1 EMBL· GenBank· DDBJ | mRNA |