B7Z8T1 · B7Z8T1_HUMAN
- Proteinpyrroline-5-carboxylate reductase
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids240 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score2/5
Function
Catalytic activity
- L-proline + NAD+ = 1-pyrroline-5-carboxylate + NADH + 2 H+
Pathway
Amino-acid biosynthesis; L-proline biosynthesis; L-proline from L-glutamate 5-semialdehyde: step 1/1.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 6-11 | NADP+ (UniProtKB | ChEBI) | |||
Binding site | 34 | NADP+ (UniProtKB | ChEBI) | |||
Binding site | 56 | NADP+ (UniProtKB | ChEBI) | |||
Binding site | 69-72 | NADP+ (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | pyrroline-5-carboxylate reductase activity | |
Biological Process | L-proline biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namepyrroline-5-carboxylate reductase
- EC number
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionB7Z8T1
PTM/Processing
Proteomic databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 3-73 | Pyrroline-5-carboxylate reductase catalytic N-terminal | |||
Domain | 153-206 | Pyrroline-5-carboxylate reductase dimerisation | |||
Sequence similarities
Belongs to the pyrroline-5-carboxylate reductase family.
Family and domain databases
Sequence
- Sequence statusComplete
- Length240
- Mass (Da)25,190
- Last updated2009-03-03 v1
- MD5 ChecksumF65089913950CD609EE270895CDA1AC9
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AK303852 EMBL· GenBank· DDBJ | BAH14067.1 EMBL· GenBank· DDBJ | mRNA |