Essential maintenance is planned to begin on Tue Jan 28 2025. The website may be temporarily unavailable. Please use our fallback: https://wwwdev.ebi.ac.uk/uniprot/front-end/fallback/ during this time.

B7Z8T1 · B7Z8T1_HUMAN

  • Protein
    pyrroline-5-carboxylate reductase
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Evidence at transcript level
  • Annotation score
    2/5

Function

Catalytic activity

Pathway

Amino-acid biosynthesis; L-proline biosynthesis; L-proline from L-glutamate 5-semialdehyde: step 1/1.

Features

Showing features for binding site.

124020406080100120140160180200220240
TypeIDPosition(s)Description
Binding site6-11NADP+ (UniProtKB | ChEBI)
Binding site34NADP+ (UniProtKB | ChEBI)
Binding site56NADP+ (UniProtKB | ChEBI)
Binding site69-72NADP+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Functionpyrroline-5-carboxylate reductase activity
Biological ProcessL-proline biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    pyrroline-5-carboxylate reductase
  • EC number

Organism names

  • Taxonomic identifier
  • Organism
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    B7Z8T1

PTM/Processing

Proteomic databases

Structure

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain3-73Pyrroline-5-carboxylate reductase catalytic N-terminal
Domain153-206Pyrroline-5-carboxylate reductase dimerisation

Sequence similarities

Belongs to the pyrroline-5-carboxylate reductase family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    240
  • Mass (Da)
    25,190
  • Last updated
    2009-03-03 v1
  • MD5 Checksum
    F65089913950CD609EE270895CDA1AC9
MSVGFIGAGQLAFALAKGFTAAGVLAAHKIMASSPDMDLATVSALRKMGVKLTPHNKETVQHSDVLFLAVKPHISSIEKLSAFRPAPRVIRCMTNTPVVVREGATVYATGTHAQVEDGRLMEQLLSSVGFCTEVEEDLIDAVTGLSGSGPAYGAAKMLLHSEQHPGQLKDNVSSPGGATIHALHVLESGGFRSLLINAVEASCIRTRWAPALPASLVSSPCMAEASLTHICSFTHSADTY

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AK303852
EMBL· GenBank· DDBJ
BAH14067.1
EMBL· GenBank· DDBJ
mRNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
Help