B7Z8K6 · TRDC_HUMAN

  • Protein
    T cell receptor delta constant
  • Gene
    TRDC
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    3/5

Function

function

Constant region of T cell receptor (TR) delta chain that participates in the antigen recognition (PubMed:24600447).
Gamma-delta TRs recognize a variety of self and foreign non-peptide antigens frequently expressed at the epithelial boundaries between the host and external environment, including endogenous lipids presented by MH-like protein CD1D and phosphoantigens presented by butyrophilin-like molecule BTN3A1. Upon antigen recognition induces rapid, innate-like immune responses involved in pathogen clearance and tissue repair (PubMed:23348415, PubMed:28920588).
Binding of gamma-delta TR complex to antigen triggers phosphorylation of immunoreceptor tyrosine-based activation motifs (ITAMs) in the CD3 chains by the LCK and FYN kinases, allowing the recruitment, phosphorylation, and activation of ZAP70 that facilitates phosphorylation of the scaffolding proteins LCP2 and LAT. This lead to the formation of a supramolecular signalosome that recruits the phospholipase PLCG1, resulting in calcium mobilization and ERK activation, ultimately leading to T cell expansion and differentiation into effector cells (PubMed:25674089).
Gamma-delta TRs are produced through somatic rearrangement of a limited repertoire of variable (V), diversity (D), and joining (J) genes. The potential diversity of gamma-delta TRs is conferred by the unique ability to rearrange (D) genes in tandem and to utilize all three reading frames. The combinatorial diversity is considerably increased by the sequence exonuclease trimming and random nucleotide (N) region additions which occur during the V-(D)-J rearrangements (PubMed:24387714).

GO annotations

AspectTerm
Cellular Componentgamma-delta T cell receptor complex
Cellular Componentplasma membrane
Biological Processadaptive immune response
Biological Processgamma-delta T cell activation
Biological ProcessT cell receptor signaling pathway

Keywords

Enzyme and pathway databases

Protein family/group databases

Names & Taxonomy

Protein names

  • Recommended name
    T cell receptor delta constant

Gene names

    • Name
      TRDC

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    B7Z8K6

Proteomes

Organism-specific databases

Subcellular Location

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane130-152Helical

Keywords

Disease & Variants

Organism-specific databases

Miscellaneous

Genetic variation databases

PTM/Processing

Features

Showing features for chain, glycosylation, disulfide bond.

TypeIDPosition(s)Description
ChainPRO_00003934731-153T cell receptor delta constant
Glycosylation14N-linked (GlcNAc...) asparagine
Disulfide bond20↔71
Glycosylation77N-linked (GlcNAc...) asparagine

Keywords

Proteomic databases

PTM databases

Expression

Organism-specific databases

Interaction

Subunit

Gamma-delta TR is a heterodimer composed of a gamma and delta chain; disulfide-linked. The gamma-delta TR is associated with the transmembrane signaling CD3 coreceptor proteins following the stoichiometry: a single gamma-delta TR heterodimer associates with one CD3D-CD3E heterodimer, one CD3G-CD3E heterodimer and one CD247 homodimer forming a stable octameric structure. Upon activation, gamma-delta TR complex associates with FCER1G to initiate intracellular signaling.
View interactors in UniProtKB
View CPX-6582 in Complex Portal

Protein-protein interaction databases

Miscellaneous

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region85-112Disordered

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    153
  • Mass (Da)
    17,085
  • Last updated
    2010-04-20 v2
  • Checksum
    B1C4D262622929E4
SQPHTKPSVFVMKNGTNVACLVKEFYPKDIRINLVSSKKITEFDPAIVISPSGKYNAVKLGKYEDSNSVTCSVQHDNKTVHSTDFEVKTDSTDHVKPKETENTKQPSKSCHKPKAIVHTEKVNMMSLTVLGLRMLFAKTVAVNFLLTAKLFFL

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
A0A075B6X2A0A075B6X2_HUMANTRDC154

Sequence caution

The sequence AAA61033.1 differs from that shown. Reason: Erroneous initiation Extended N-terminus.
The sequence BAH13992.1 differs from that shown. Reason: Erroneous initiation Truncated N-terminus.

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1

Polymorphism

There are several alleles. The sequence shown is that of IMGT allele TRDC*01.

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
M22150
EMBL· GenBank· DDBJ
AAA61033.1
EMBL· GenBank· DDBJ
Genomic DNA Different initiation
M22148
EMBL· GenBank· DDBJ
AAA61033.1
EMBL· GenBank· DDBJ
Genomic DNA Different initiation
M22149
EMBL· GenBank· DDBJ
AAA61033.1
EMBL· GenBank· DDBJ
Genomic DNA Different initiation
AK303587
EMBL· GenBank· DDBJ
BAH13992.1
EMBL· GenBank· DDBJ
mRNA Different initiation
AC244502
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.

Similar Proteins

Disclaimer

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