B7Z7U4 · B7Z7U4_HUMAN

  • Protein
    Tyrosine-protein kinase receptor
  • Gene
    NTRK3
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    3/5

Function

Catalytic activity

Features

Showing features for binding site, active site.

161750100150200250300350400450500550600
TypeIDPosition(s)Description
Binding site446-454ATP (UniProtKB | ChEBI)
Binding site447-454ATP (UniProtKB | ChEBI)
Binding site474ATP (UniProtKB | ChEBI)
Binding site520-526ATP (UniProtKB | ChEBI)
Active site581Proton acceptor
Binding site585ATP (UniProtKB | ChEBI)
Binding site586Mg2+ (UniProtKB | ChEBI)
Binding site599Mg2+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentplasma membrane
Molecular FunctionATP binding
Molecular Functionmetal ion binding
Molecular Functionneurotrophin receptor activity
Molecular Functiontransmembrane receptor protein tyrosine kinase activity
Biological Processcell differentiation
Biological Processcell surface receptor protein tyrosine kinase signaling pathway
Biological Processnervous system development

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Tyrosine-protein kinase receptor
  • EC number

Gene names

    • Name
      NTRK3

Organism names

  • Taxonomic identifier
  • Organism
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    B7Z7U4

Proteomes

Organism-specific databases

Subcellular Location

Membrane
; Single-pass type I membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane332-355Helical

Keywords

  • Cellular component

Disease & Variants

Variants

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The viewer provides 2,141 variants from UniProt as well as other sources including ClinVar and dbSNP.

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Organism-specific databases

Genetic variation databases

PTM/Processing

Keywords

Proteomic databases

Expression

Gene expression databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain112-202Ig-like
Domain440-617Protein kinase

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    617
  • Mass (Da)
    69,020
  • Last updated
    2009-03-03 v1
  • Checksum
    E34D5A963FFB1CB1
MELYTGLQKLTIKNSGLRSIQPRAFAKNPHLRYINLSSNRLTTLSWQLFQTLSLRELQLEQNFFNCSCDIRWMQLWQEQGEAKLNSQNLYCINADGSQLPLFRMNISQCDLPEISVSHVNLTVREGDNAVITCNGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDNGFTLTCIAENVVGMSNASVALTVYYPPRVVSLEEPELRLEHCIEFVVRGNPPPTLHWLHNGQPLRESKIIHVEYYQEGEISEGCLLFNKPTHYNNGNYTLIAKNPLGTANQTINGHFLKEPFPESTDNFILFDEVSPTPPITVTHKPEEDTFGVSIAVGLAAFACVLLVVLFVMINKYGRRSKFGMKGPVAVISGEEDSASPLHHINHGITTPSSLDAGPDTVVIGMTRIPVIENPQYFRQGHNCHKPDTYVQHIKRRDIVLKRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDYYRVVQA

Computationally mapped potential isoform sequences

There are 8 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
Q16288NTRK3_HUMANNTRK3839
H0YM90H0YM90_HUMANNTRK3705
A0A0D9SFP6A0A0D9SFP6_HUMANNTRK3864
R4GNH5R4GNH5_HUMANNTRK390
R4GMR8R4GMR8_HUMANNTRK3146
R4GN40R4GN40_HUMANNTRK385
A0A8Q3SHY2A0A8Q3SHY2_HUMANNTRK3506
A0A087WX31A0A087WX31_HUMANNTRK349

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AC009711
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AC011966
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AC021677
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AK302504
EMBL· GenBank· DDBJ
BAH13730.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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