B7Z7U4 · B7Z7U4_HUMAN
- ProteinTyrosine-protein kinase receptor
- GeneNTRK3
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids617 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score3/5
Function
Catalytic activity
- ATP + L-tyrosyl-[protein] = ADP + H+ + O-phospho-L-tyrosyl-[protein]
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 446-454 | ATP (UniProtKB | ChEBI) | ||||
Sequence: LGEGAFGKV | ||||||
Binding site | 447-454 | ATP (UniProtKB | ChEBI) | ||||
Sequence: GEGAFGKV | ||||||
Binding site | 474 | ATP (UniProtKB | ChEBI) | ||||
Sequence: K | ||||||
Binding site | 520-526 | ATP (UniProtKB | ChEBI) | ||||
Sequence: EYMKHGD | ||||||
Active site | 581 | Proton acceptor | ||||
Sequence: D | ||||||
Binding site | 585 | ATP (UniProtKB | ChEBI) | ||||
Sequence: R | ||||||
Binding site | 586 | Mg2+ (UniProtKB | ChEBI) | ||||
Sequence: N | ||||||
Binding site | 599 | Mg2+ (UniProtKB | ChEBI) | ||||
Sequence: D |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | plasma membrane | |
Molecular Function | ATP binding | |
Molecular Function | metal ion binding | |
Molecular Function | neurotrophin receptor activity | |
Molecular Function | transmembrane receptor protein tyrosine kinase activity | |
Biological Process | cell differentiation | |
Biological Process | cell surface receptor protein tyrosine kinase signaling pathway | |
Biological Process | nervous system development |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameTyrosine-protein kinase receptor
- EC number
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionB7Z7U4
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Membrane ; Single-pass type I membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 332-355 | Helical | ||||
Sequence: FGVSIAVGLAAFACVLLVVLFVMI |
Keywords
- Cellular component
Disease & Variants
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 2,141 variants from UniProt as well as other sources including ClinVar and dbSNP.
Organism-specific databases
Genetic variation databases
PTM/Processing
Expression
Gene expression databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 112-202 | Ig-like | ||||
Sequence: PEISVSHVNLTVREGDNAVITCNGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDNGFTLTCIAENVVGMSNASVALT | ||||||
Domain | 440-617 | Protein kinase | ||||
Sequence: IVLKRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDYYRVVQA |
Sequence similarities
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length617
- Mass (Da)69,020
- Last updated2009-03-03 v1
- ChecksumE34D5A963FFB1CB1
Computationally mapped potential isoform sequences
There are 8 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
Q16288 | NTRK3_HUMAN | NTRK3 | 839 | ||
H0YM90 | H0YM90_HUMAN | NTRK3 | 705 | ||
A0A0D9SFP6 | A0A0D9SFP6_HUMAN | NTRK3 | 864 | ||
R4GNH5 | R4GNH5_HUMAN | NTRK3 | 90 | ||
R4GMR8 | R4GMR8_HUMAN | NTRK3 | 146 | ||
R4GN40 | R4GN40_HUMAN | NTRK3 | 85 | ||
A0A8Q3SHY2 | A0A8Q3SHY2_HUMAN | NTRK3 | 506 | ||
A0A087WX31 | A0A087WX31_HUMAN | NTRK3 | 49 |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AC009711 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AC011966 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AC021677 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AK302504 EMBL· GenBank· DDBJ | BAH13730.1 EMBL· GenBank· DDBJ | mRNA |