B7Z7Q4 · B7Z7Q4_HUMAN

  • Protein
    Protein O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Evidence at transcript level
  • Annotation score
    3/5

Function

function

Participates in O-mannosyl glycosylation by catalyzing the addition of N-acetylglucosamine to O-linked mannose on glycoproteins. Catalyzes the synthesis of the GlcNAc(beta1-2)Man(alpha1-)O-Ser/Thr moiety on alpha-dystroglycan and other O-mannosylated proteins, providing the necessary basis for the addition of further carbohydrate moieties. Is specific for alpha linked terminal mannose.

Cofactor

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Note: The manganese ion interacts primarily with the substrate UDP-N-acetylglucosamine.

Pathway

Protein modification; protein glycosylation.

GO annotations

AspectTerm
Cellular ComponentGolgi membrane
Molecular Functionacetylglucosaminyltransferase activity
Molecular Functioncarbohydrate binding
Molecular Functionmanganese ion binding
Biological Processprotein glycosylation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Protein O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase
  • EC number
  • Short names
    POMGnT1

Organism names

  • Taxonomic identifier
  • Organism
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    B7Z7Q4

Subcellular Location

Golgi apparatus membrane
; Single-pass type II membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane20-37Helical

Keywords

Disease & Variants

Organism-specific databases

PTM/Processing

Keywords

Proteomic databases

Interaction

Subunit

Interacts with DAG1 (via O-linked mannose moiety). Interacts (via transmembrane domain) with FKTN; the interaction is direct and is required for normal location in Golgi membranes.

Family & Domains

Features

Showing features for region, compositional bias, domain.

TypeIDPosition(s)Description
Region46-74Disordered
Compositional bias56-74Basic and acidic residues
Domain107-196ILEI/PANDER
Region612-638Disordered

Domain

The stem domain mediates specific interaction with beta-linked N-acetylglucosamine moieties of O-glycosylated proteins. It also interacts with its product, N-acetyl-beta-D-glucosaminyl-(1->2)-O-alpha-D-mannosylprotein.

Sequence similarities

Belongs to the glycosyltransferase 13 family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    638
  • Mass (Da)
    72,447
  • Last updated
    2009-03-03 v1
  • Checksum
    6B9D4E06B80E7116
MEGTKEIKVSNRRIQEHWTGAVLFLLVTVIVNIKLILDTRRAISEANEDPEPEQDYDEALGRLEPPRRRGSGPRRVLDVEVYSSRSKVYVAVDGTTVLEDEAREQGRGIHVIVLNQATGHVMAKRVFDTYSPHEDEAMVLFLNMVAPGRVLICTVKDEGSFHLKDTAKALLRSLGSQAGPALGWRDTWAFVGRKGGPVFGEKHSKSPALSSWGDPVLLKTDVPLSSAEEAECHWADTELNRRRRRFCSKVEGYGSVCSCKDPTPIEFSPDPLPDNKVLNVPVAVIAGNRPNYLYRMLRSLLSAQGVSPQMITVFIDGYYEEPMDVVALFGLRGIQHTPISIKNARVSQHYKASLTATFNLFPEAKFAVVLEEDLDIAVDFFSFLSQSIHLLEEDDSLYCISAWNDQGYEHTAEDPALLYRVETMPGLGWVLRRSLYKEELEPKWPTPEKLWDWDMWMRMPEQRRGRECIIPDVSRSYHFGIVGLNMNGYFHEAYFKKHKFNTVPGVQLRNVDSLKKEAYEVEVHRLLSEAEVLDHSKNPCEDSFLPDTEGHTYVAFIRMEKDDDFTTWTQLAKCLHIWDLDVRGNHRGLWRLFRKKNHFLVVGVPASPYSVKKPPSVTPIFLEPPPKEEGAPGAPEQT

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias56-74Basic and acidic residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AK302379
EMBL· GenBank· DDBJ
BAH13690.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

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