B7Z7G9 · B7Z7G9_HUMAN

  • Protein
    Glucosylceramidase
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Evidence at transcript level
  • Annotation score
    4/5

Function

Catalytic activity

  • 1-(beta-D-galactosyl)-N-dodecanoylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-galactoside + N-dodecanoylsphing-4-enine
    This reaction proceeds in the forward
    and the backward
    directions.
  • a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + H2O = an N-acylsphing-4-enine + D-galactose
    This reaction proceeds in the forward direction.
    EC:3.2.1.46 (UniProtKB | ENZYME | Rhea)
  • a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + cholesterol = an N-acylsphing-4-enine + cholesteryl 3-beta-D-galactoside
    This reaction proceeds in the forward
    and the backward
    directions.
  • a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H2O = an N-acylsphing-4-enine + D-glucose
    This reaction proceeds in the forward direction.
    EC:3.2.1.45 (UniProtKB | ENZYME | Rhea)
  • a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + cholesterol = an N-acylsphing-4-enine + cholesteryl 3-beta-D-glucoside
    This reaction proceeds in the forward
    and the backward
    directions.
  • a beta-D-xylosyl-(1<->1')-N-acylsphing-4-enine + cholesterol = an N-acylsphing-4-enine + cholesteryl 3-beta-D-xyloside
    This reaction proceeds in the forward direction.
  • beta-D-glucosyl-(1<->1')-N-(15Z-tetracosenoyl)-sphing-4-enine + cholesterol = cholesteryl 3-beta-D-glucoside + N-(15Z-tetracosenoyl)-sphing-4-enine
    This reaction proceeds in the forward
    and the backward
    directions.
  • beta-D-glucosyl-(1<->1)-N-octadecanoylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-glucoside + N-octadecanoylsphing-4-enine
    This reaction proceeds in the forward
    and the backward
    directions.
  • beta-D-glucosyl-N-(9Z-octadecenoyl)-sphing-4E-enine + cholesterol = cholesteryl 3-beta-D-glucoside + N-(9Z-octadecenoyl)-sphing-4-enine
    This reaction proceeds in the forward
    and the backward
    directions.
  • beta-D-glucosyl-N-dodecanoylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-glucoside + N-dodecanoylsphing-4-enine
    This reaction proceeds in the forward
    and the backward
    directions.
  • beta-D-glucosyl-N-octanoylsphing-4E-enine + cholesterol = cholesteryl 3-beta-D-glucoside + N-octanoylsphing-4-enine
    This reaction proceeds in the forward
    and the backward
    directions.
  • beta-D-xylosyl-(1<->1')-N-(9Z-octadecenoyl)-sphing-4-enine + cholesterol = cholesteryl 3-beta-D-xyloside + N-(9Z-octadecenoyl)-sphing-4-enine
    This reaction proceeds in the forward direction.
  • cholesteryl 3-beta-D-glucoside + H2O = cholesterol + D-glucose
    This reaction proceeds in the forward direction.

Pathway

Sphingolipid metabolism.
Steroid metabolism; cholesterol metabolism.

GO annotations

AspectTerm
Cellular Componentlysosomal membrane
Molecular Functiongalactosylceramidase activity
Molecular Functionglucosylceramidase activity
Molecular Functionglycosyltransferase activity
Molecular Functionsteryl-beta-glucosidase activity
Biological Processcholesterol metabolic process
Biological Processglucosylceramide catabolic process

Keywords

Enzyme and pathway databases

Protein family/group databases

Names & Taxonomy

Protein names

  • Recommended name
    Glucosylceramidase
  • EC number

Organism names

  • Taxonomic identifier
  • Organism
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    B7Z7G9

Subcellular Location

Lysosome membrane
; Peripheral membrane protein

Disease & Variants

Protein family/group databases

PTM/Processing

Proteomic databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain74-423Glycosyl hydrolase family 30 TIM-barrel
Domain426-488Glycosyl hydrolase family 30 beta sandwich

Sequence similarities

Belongs to the glycosyl hydrolase 30 family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    493
  • Mass (Da)
    55,401
  • Last updated
    2009-03-03 v1
  • Checksum
    394AB7550943E9A9
MTLRGWSFQVLPERNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AK302000
EMBL· GenBank· DDBJ
BAH13605.1
EMBL· GenBank· DDBJ
mRNA

Similar Proteins

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