study shows that cytoplasmic hereditary spherocytosis mutants cause impaired binding of protein 4.2 to AE1 leaving protein 4.2 susceptible to loss during erythrocyte development
Data suggest that one or both of proteins 4.1 and 4.2 cause a portion of band 3 to localize near the spectrin-actin junctions and provide another point of attachment between the membrane skeleton and the lipid bilayer.
Current understanding of protein 4.2 its known interactions & implications of protein 4.2 deficiency are reviewed. A new speculative "open" homology structure for the the active membrane associated form is proposed. Review.
The interactions of three protein 4.2-derived recombinant proteins with CDB3 and ankyrin were investigated by using Far-Western blot and pull-down assay.
Evidence protein 4.2 interacts with the Rh membrane complex member CD47 obtained from red cells of patients with hereditary spherocytosis associated with complete protein 4.2 deficiency
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