B7Z4Q5 · B7Z4Q5_HUMAN
- ProteinReceptor-type tyrosine-protein phosphatase alpha
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids647 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score2/5
Function
Catalytic activity
- H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 255 | substrate | ||||
Sequence: D | ||||||
Active site | 287 | Phosphocysteine intermediate | ||||
Sequence: C | ||||||
Binding site | 287-293 | substrate | ||||
Sequence: CSAGVGR | ||||||
Binding site | 331 | substrate | ||||
Sequence: Q | ||||||
Active site | 577 | Phosphocysteine intermediate | ||||
Sequence: C |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | plasma membrane | |
Molecular Function | protein tyrosine phosphatase activity |
Keywords
- Molecular function
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameReceptor-type tyrosine-protein phosphatase alpha
- EC number
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionB7Z4Q5
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Single-pass type I membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 6-22 | Helical | ||||
Sequence: SLLVIVFIIIVLYMLRF |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for modified residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Modified residue | 643 | Phosphotyrosine | ||||
Sequence: Y |
Keywords
- PTM
Proteomic databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 86-346 | Tyrosine-protein phosphatase | ||||
Sequence: FREEFNALPACPIQATCEAASKEENKEKNRYVNILPYDHSRVHLTPVEGVPDSDYINASFINGYQEKNKFIAAQGPKEETVNDFWRMIWEQNTATIVMVTNLKERKECKCAQYWPDQGCWTYGNIRVSVEDVTVLVDYTVRKFCIQQVGDMTNRKPQRLITQFHFTSWPDFGVPFTPIGMLKFLKKVKACNPQYAGAIVVHCSAGVGRTATFVVIDAMLDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLEH | ||||||
Domain | 266-337 | Tyrosine specific protein phosphatases | ||||
Sequence: LKFLKKVKACNPQYAGAIVVHCSAGVGRTATFVVIDAMLDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYV | ||||||
Domain | 378-636 | Tyrosine-protein phosphatase | ||||
Sequence: LEEEFKKLTSIKIQNDKMRTGNLPANMKKNRVLQIIPYEFNRVIIPVKRGEENTDYVNASFIDGYRQKDSYIASQGPLLHTIEDFWRMIWEWKSCSIVMLTELEERGQEKCAQYWPSDGLVSYGDITVELKKEEECESYTVRDLLVTNTRENKSRQIRQFHFHGWPEVGIPSDGKGMISIIAAVQKQQQQSGNHPITVHCSAGAGRTGTFCALSTVLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEY | ||||||
Domain | 552-627 | Tyrosine specific protein phosphatases | ||||
Sequence: KGMISIIAAVQKQQQQSGNHPITVHCSAGAGRTGTFCALSTVLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQYE |
Sequence similarities
Belongs to the protein-tyrosine phosphatase family. Receptor class 4 subfamily.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length647
- Mass (Da)74,556
- Last updated2009-03-03 v1
- ChecksumBAE59069A4A1A789