The catalytically important residues are Asp148 and Glu149 with Glu149 serving as the general acid/base residue and Asp148 as the polarizing residue. HexD is inhibited by Gal-NAG-thiazoline (Ki = 420 nM).
the expression and disease relevance of the HEXDC gene in humans demonstrate the expression of this novel enzyme within the joints and suggests that its activity may significantly contribute to the overall local exoglycosidase activity.
Studies indicate the most studied biomarkers for acute kidney injury are neutrophil gelatinase-associated lipocalin-2 kidney injury molecule-1 IL-18 cystatin C N-acetyl-beta-D-glucosaminidase liver fatty-acid binding protein and heat shock protein 72.
The results suggest that following coronary angiography and/or percutaneous coronary intervention contrast-induced nephropathy (CIN) occurs to a certain degree and that NAG may be a useful early CIN marker.
In normoalbuminuric/microalbuminuric patients with essential hypertension renal impairment measured by e-GFR is related to the increased urinary NAG activity and albumin/creatinine ratio rather than elevated concentrations of individual proteins.
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