Adipose Mesenchymal Stem Cell-derived Exosomes Enhanced Glycolysis through the SIX1/HBO1 Pathway against Oxygen and Glucose Deprivation Injury in Human Umbilical Vein Endothelial Cells.
identify the MYST acetyltransferase HBO1 (also known as KAT7 or MYST2) and several known members of the HBO1 protein complex as critical regulators of leukaemia stem cells maintenance
HBO1 is essential for H3K14 acetylation but HBO1 is dispensable for DNA replication and cell proliferation in immortalized human cells. HBO1 gene deletion led to profound changes in cell adhesion particularly in 293T cells.
As the core catalytic subunit HBO1 consists of an N-terminal domain and a C-terminal MYST domain that are in charge of acetyl-CoA binding and acetylation reaction. This paper reviews the recent advances and discusses the understanding of the multiple functions activity regulation and disease relationship of HBO1. (review)
These data suggest that LYAR promotes the association of the BRD2-KAT7 and BRD4-KAT7 complexes with transcription-competent rDNA loci but not to transcriptionally silent rDNA loci thereby increasing rRNA synthesis by altering the local acetylation status of histone H3 and H4.
HBO1 preferentially acetylates histone H4 through the concomitant overexpression of co-regulator JADE2 and is required for the expression of YAP1 an ovarian cancer oncogene and mechano-transductor signaling factor.
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