B7Z3W6 · B7Z3W6_HUMAN

  • Protein
    Protein kinase C
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Evidence at transcript level
  • Annotation score
    3/5

Function

Catalytic activity

Cofactor

Ca2+ (UniProtKB | Rhea| CHEBI:29108 )

Note: Binds 3 Ca2+ ions per subunit. The ions are bound to the C2 domain.

Features

Showing features for binding site, active site.

1710100200300400500600700
TypeIDPosition(s)Description
Binding site186Ca2+ 1 (UniProtKB | ChEBI)
Binding site187Ca2+ 2 (UniProtKB | ChEBI)
Binding site193Ca2+ 2 (UniProtKB | ChEBI)
Binding site195a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) (UniProtKB | ChEBI)
Binding site245a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) (UniProtKB | ChEBI)
Binding site246Ca2+ 2 (UniProtKB | ChEBI)
Binding site247Ca2+ 2 (UniProtKB | ChEBI)
Binding site248Ca2+ 2 (UniProtKB | ChEBI)
Binding site251Ca2+ 3 (UniProtKB | ChEBI)
Binding site252Ca2+ 3 (UniProtKB | ChEBI)
Binding site254Ca2+ 1 (UniProtKB | ChEBI)
Binding site357-365ATP (UniProtKB | ChEBI)
Binding site380ATP (UniProtKB | ChEBI)
Active site480Proton acceptor

GO annotations

AspectTerm
Cellular Componentdendrite
Cellular Componentperinuclear region of cytoplasm
Cellular Componentplasma membrane
Cellular Componentsynapse
Molecular FunctionATP binding
Molecular Functiondiacylglycerol-dependent serine/threonine kinase activity
Molecular Functionprotein serine kinase activity
Molecular Functionzinc ion binding
Biological Processprotein phosphorylation
Biological Processregulation of primary metabolic process
Biological Processrhythmic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Protein kinase C
  • EC number

Organism names

  • Taxonomic identifier
  • Organism
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    B7Z3W6

Subcellular Location

Cell membrane
; Peripheral membrane protein
Cell projection, dendrite
Cytoplasm, perinuclear region
Synapse, synaptosome

Keywords

Disease & Variants

Organism-specific databases

PTM/Processing

Keywords

Proteomic databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain35-85Phorbol-ester/DAG-type
Domain100-150Phorbol-ester/DAG-type
Domain157-275C2
Domain351-614Protein kinase
Domain615-685AGC-kinase C-terminal

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    710
  • Mass (Da)
    79,720
  • Last updated
    2009-03-03 v1
  • Checksum
    1F4E2E5066C9996A
MAGLGPGVGDSEGGPRPLFCRKGALRQKVVHEVKSHKFTARFFKQPTFCSHCTDFIWGIGKQGLQCQVCSFVVHRRCHEFVTFECPGAGKGPQTDDPRNKHKFRLHSYSSPTFCDHCGSLLYGLVHQGMKCSCCEMNVHRRCVRSVPSLCGVDHTERRGRLQLEIRAPTADEIHVTVGEARNLIPMDPNGLSDPYVKLKLIPDPRNLTKQKTRTVKATLNPVWNETFVFNLKPGDVERRLSVEVWDWDRTSRNDFMGAMSFGVSELLKAPVDGWYKLLNQEEGEYYNVPVADADNCSLLQKFEACNYPLELYERVRMGPSSSPIPSPSPSPTDPKRCFFGASPGRLHISGFSFLMVLGKGSFGKVMLAERRGSDELYAIKILKKDVIVQDDDVDCTLVEKRVLALGGRGPGGRPHFLTQLHSTFQTPDRLYFVMEYVTGGDLMYHIQQLGKFKEPHAAFYAAEIAIGLFFLHNQGIIYRDLKLDNVMLDAEGHIKITDFGMCKENVFPGTTTRTFCGTPDYIAPEIIAYQPYGKSVDWWSFGVLLYEMLAGQPPFDGEDEEELFQAIMEQTVTYPKSLSREAVAICKGFLTKHPGKRLGSGPDGEPTIRAHGFFRWIDWERLERLEIPPPFRPRPCGRSGENFDKFFTRAAPALTPPDRLVLASIDQADFQGFTYVNPDFVHPDARSPTSPVPVPVISCTPAFQLCPRGS

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AK296434
EMBL· GenBank· DDBJ
BAH12352.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp