B7Z3U1 · B7Z3U1_HUMAN
- Proteinlong-chain-fatty-acid--CoA ligase
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids646 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score2/5
Function
Catalytic activity
- ATP + CoA + tetracosanoate = AMP + diphosphate + tetracosanoyl-CoAThis reaction proceeds in the forward direction.
- a very long-chain fatty acid + ATP + CoA = a very long-chain fatty acyl-CoA + AMP + diphosphateThis reaction proceeds in the forward direction.
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | ligase activity | |
Molecular Function | nucleotide binding | |
Biological Process | fatty acid transport | |
Biological Process | lipid metabolic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namelong-chain-fatty-acid--CoA ligase
- EC number
- Alternative names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionB7Z3U1
PTM/Processing
Proteomic databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 82-432 | AMP-dependent synthetase/ligase | ||||
Sequence: FQAVVQRQPERLALVDAGTGECWTFAQLDAYSNAVANLFRQLGFAPGDVVAIFLEGRPEFVGLWLGLAKAGMEAALLNVNLRREPLAFCLGTSGAKALIFGGEMVAAVAEVSGHLGKSLIKFCSGDLGPEGILPDTHLLDPLLKEASTAPLAQIPSKGMDDRLFYIYTSGTTGLPKAAIVVHSRYYRMAAFGHHAYRMQAADVLYDCLPLYHSAGNIIGVGQCLIYGLTVVLRKKFSASRFWDDCIKYNCTVVQYIGEICRYLLKQPVREAERRHRVRLAVGSGLRPAIWEEFTERFGVRQIGEFYGATECNCSIANMDGKVGSCGFNSRILPHVYPIRLVKVNEDTMELL | ||||||
Domain | 523-598 | AMP-binding enzyme C-terminal | ||||
Sequence: EVEGVLSRLLGQTDVAVYGVAVPGVEGKAGMAAVADPHSLLDPNAIYQELQKVLAPYARPIFLRLLPQVDTTGTFK |
Sequence similarities
Belongs to the ATP-dependent AMP-binding enzyme family.
Family and domain databases
Sequence
- Sequence statusComplete
- Length646
- Mass (Da)71,081
- Last updated2009-03-03 v1
- ChecksumB856BDDA779C6BDF