results that validate the newly developed structural homology model of CNT membrane architecture for human CNTs revealed extended conformationally mobile regions within transport-domain TMs identified pore-lining residues of functional importance and provided evidence of an emerging novel elevator-type mechanism of transporter function.
Brazilian Amerindian ancestry compared to Asian European and African Genomes.SNPs within or proximal to CIITA (rs6498115) SMC6 (rs1834619) and KLHL29 (rs2288697) were most differentiated in the Amerindian-specific branch. SNPs in ADAMTS9 (rs7631391) DOCK2 (rs77594147) SLC28A1 (rs28649017) ARHGAP5 (rs7151991) and CIITA (rs45601437) in the Asian comparison.
ErbB2 modulates gemcitabine and irinotecan/SN-38 chemoresistance of human pancreatic cancer cells via hCNT1 transporter and multidrug-resistance associated protein MRP-2.
Site-directed mutagenesis analysis reveals that only one sodium binding site is affected by a mutation; lack of serine546 residue is responsible for apparent loss of CNT1 function.
variability in hCNT1 and hENT1 expression in tumour and normal human breast tissue with different expression patterns related to patient prognosis and clinical outcome.
Observational study of gene-disease association gene-gene interaction gene-environment interaction and pharmacogenomic / toxicogenomic. (HuGE Navigator)
Observational study of gene-disease association gene-environment interaction and pharmacogenomic / toxicogenomic. (HuGE Navigator); In nonsmall cell lung cancer CNT1 565A showed a borderline significant positive influence on the early response for carriers of the variant allele which however did not translate to the survival of the patients
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.