B7Z2P9 · B7Z2P9_HUMAN
- ProteinE3 ubiquitin-protein ligase
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids835 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score2/5
Function
Catalytic activity
Pathway
Protein modification; protein ubiquitination.
Features
Showing features for active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 802 | Glycyl thioester intermediate | ||||
Sequence: C |
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | sodium channel inhibitor activity | |
Molecular Function | ubiquitin protein ligase activity | |
Biological Process | negative regulation of potassium ion transmembrane transport | |
Biological Process | protein polyubiquitination | |
Biological Process | regulation of dendrite morphogenesis | |
Biological Process | ubiquitin-dependent protein catabolic process |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameE3 ubiquitin-protein ligase
- EC number
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionB7Z2P9
Subcellular Location
UniProt Annotation
GO Annotation
Disease & Variants
Organism-specific databases
PTM/Processing
Proteomic databases
Structure
Family & Domains
Features
Showing features for region, compositional bias, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 32-81 | Disordered | ||||
Sequence: MPKNGGQDEENSDQRDDMEHGWEVVDSNDSASQHQEELPPPPLPPGWEEK | ||||||
Compositional bias | 39-55 | Basic and acidic residues | ||||
Sequence: DEENSDQRDDMEHGWEV | ||||||
Domain | 72-105 | WW | ||||
Sequence: PPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSL | ||||||
Compositional bias | 123-140 | Basic and acidic residues | ||||
Sequence: AAHRRFRSRRHISEDLEP | ||||||
Region | 123-151 | Disordered | ||||
Sequence: AAHRRFRSRRHISEDLEPEPSEGGDVPEP | ||||||
Region | 164-190 | Disordered | ||||
Sequence: DSRGLALPPPPASPGSRTSPQGLSEEL | ||||||
Domain | 244-277 | WW | ||||
Sequence: PGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIM | ||||||
Compositional bias | 283-314 | Polar residues | ||||
Sequence: GASGSATNSNNHLIEPQIRRPRSLSSPTVTLS | ||||||
Region | 283-353 | Disordered | ||||
Sequence: GASGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQPSPYNSPKPQHKV | ||||||
Domain | 356-389 | WW | ||||
Sequence: SFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRL | ||||||
Domain | 407-440 | WW | ||||
Sequence: GPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRL | ||||||
Domain | 500-834 | HECT | ||||
Sequence: RPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEEDFGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGFEGV |
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length835
- Mass (Da)96,399
- Last updated2009-03-03 v1
- Checksum29BDAFCE06FC62F8
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 39-55 | Basic and acidic residues | ||||
Sequence: DEENSDQRDDMEHGWEV | ||||||
Compositional bias | 123-140 | Basic and acidic residues | ||||
Sequence: AAHRRFRSRRHISEDLEP | ||||||
Compositional bias | 283-314 | Polar residues | ||||
Sequence: GASGSATNSNNHLIEPQIRRPRSLSSPTVTLS |
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AK294963 EMBL· GenBank· DDBJ | BAH11935.1 EMBL· GenBank· DDBJ | mRNA |