B7XGA6 · B7XGA6_MOUSE

  • Protein
    Alkaline phosphatase
  • Gene
    Alpl
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Evidence at transcript level
  • Annotation score
    5/5

Function

Catalytic activity

  • ADP + H2O = AMP + H+ + phosphate
    This reaction proceeds in the forward direction.
  • AMP + H2O = adenosine + phosphate
    This reaction proceeds in the forward direction.
  • ATP + H2O = ADP + H+ + phosphate
    This reaction proceeds in the forward direction.
  • H2O + N-phosphocreatine = creatine + phosphate
    This reaction proceeds in the forward direction.
    EC:3.9.1.1 (UniProtKB | ENZYME | Rhea)
  • H2O + phosphoethanolamine = ethanolamine + phosphate
    This reaction proceeds in the forward direction.
  • H2O + pyridoxal 5'-phosphate = phosphate + pyridoxal
    This reaction proceeds in the forward direction.
  • a phosphate monoester + H2O = an alcohol + phosphate
    This reaction proceeds in the forward direction.
    EC:3.1.3.1 (UniProtKB | ENZYME | Rhea)
  • diphosphate + H2O = H+ + 2 phosphate
    This reaction proceeds in the forward direction.

Cofactor

Protein has several cofactor binding sites:
Ca2+ (UniProtKB | Rhea| CHEBI:29108 )

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 1 Mg2+ ion.
Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 2 Zn2+ ions.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site60Mg2+ (UniProtKB | ChEBI)
Binding site60Zn2+ 2 (UniProtKB | ChEBI)
Active site110Phosphoserine intermediate
Binding site171Mg2+ (UniProtKB | ChEBI)
Binding site173Mg2+ (UniProtKB | ChEBI)
Binding site332Mg2+ (UniProtKB | ChEBI)
Binding site337Zn2+ 2 (UniProtKB | ChEBI)
Binding site341Zn2+ 2 (UniProtKB | ChEBI)
Binding site378Zn2+ 2 (UniProtKB | ChEBI)
Binding site379Zn2+ 2 (UniProtKB | ChEBI)
Binding site454Zn2+ 2 (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentmitochondrial intermembrane space
Cellular Componentmitochondrial membrane
Cellular Componentplasma membrane
Cellular Componentside of membrane
Molecular FunctionADP phosphatase activity
Molecular Functionalkaline phosphatase activity
Molecular FunctionATP hydrolysis activity
Molecular Functioninorganic diphosphate phosphatase activity
Molecular Functionmetal ion binding
Molecular Functionphosphoamidase activity
Molecular Functionphosphoethanolamine phosphatase activity
Molecular Functionpyridoxal phosphatase activity

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Alkaline phosphatase
  • EC number

Gene names

    • Name
      Alpl

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • Balb/c
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    B7XGA6

Organism-specific databases

Subcellular Location

Cell membrane
; Lipid-anchor, GPI-anchor
Extracellular vesicle membrane
; Lipid-anchor, GPI-anchor
Membrane
; Lipid-anchor, GPI-anchor
Mitochondrion membrane
; Lipid-anchor, GPI-anchor

Keywords

PTM/Processing

Features

Showing features for signal, chain.

TypeIDPosition(s)Description
Signal1-17
ChainPRO_500286366918-524Alkaline phosphatase

Keywords

Proteomic databases

PTM databases

Interaction

Subunit

Homodimer.

Protein-protein interaction databases

Family & Domains

Sequence similarities

Belongs to the alkaline phosphatase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    524
  • Mass (Da)
    57,470
  • Last updated
    2009-03-03 v1
  • Checksum
    7821200546ABE07A
MISPFLVLAIGTCLTNSFVPEKERDPSYWRQQAQETLKNALKLQKLNTNVAKNVIMFLGDGMGVSTVTAARILKGQLHHNTGEETRLEMDKFPFVALSKTYNTNAQVPDSAGTATAYLCGVKANEGTVGVSAATERTRCNTTQGNEVTSILRWAKDAGKSVGIVTTTRVNHATPSAAYAHSADRDWYSDNEMPPEALSQGCKDIAYQLMHNIKDIDVIMGGGRKYMYPKNRTDVEYELDEKARGTRLDGLDLISIWKSFKPRHKHSHYVWNRTELLALDPSRVDYLLGLFEPGDMQYELNRNNLTDPSLSEMVEVALQILTKNPKGFFLLVEGGRIDHGHHEGKAKQALHEAVEMDQAIGKAGAMTSQKDTLTVVTADHSHVFTFGGYTPRGNSIFGLAPMVSDTDKKPFTAILYGNGPGYKVVDGERENVSMVDYAHNNYQAQSAVPLRHETHGGEDVAVFAKGPMAHLLHGVHEQNYIPHVMAYASCIGANLDHCAWAGSGSAPSPGALLLPLAVLSLRTLF

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AB473959
EMBL· GenBank· DDBJ
BAH03518.1
EMBL· GenBank· DDBJ
mRNA

Similar Proteins

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