B7UBT9 · B7UBT9_9CARA
- ProteinNADH-ubiquinone oxidoreductase chain 5
- GeneND5
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids355 (go to sequence)
- Protein existencePredicted
- Annotation score2/5
Function
function
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
Catalytic activity
- a ubiquinone + 5 H+(in) + NADH = a ubiquinol + 4 H+(out) + NAD+
a ubiquinone RHEA-COMP:9565 + 5 H+ (in)CHEBI:15378+ CHEBI:57945 = a ubiquinol RHEA-COMP:9566 + 4 H+ (out)CHEBI:15378+ CHEBI:57540
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | mitochondrial respiratory chain complex I | |
Molecular Function | NADH dehydrogenase (ubiquinone) activity | |
Molecular Function | NADH dehydrogenase activity | |
Biological Process | ATP synthesis coupled electron transport | |
Biological Process | electron transport coupled proton transport |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameNADH-ubiquinone oxidoreductase chain 5
- EC number
- Alternative names
Gene names
Encoded on
- Mitochondrion
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Coleoptera > Adephaga > Caraboidea > Carabidae > Carabinae > Carabini > Carabina > Carabus > Coptolabrus
Accessions
- Primary accessionB7UBT9
Subcellular Location
UniProt Annotation
GO Annotation
Membrane ; Multi-pass membrane protein
Mitochondrion inner membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 25-44 | Helical | ||||
Sequence: LFLLLISSLTMFMAGLGANF | ||||||
Transmembrane | 51-69 | Helical | ||||
Sequence: IIALSTLSQLGLMMSILSM | ||||||
Transmembrane | 75-97 | Helical | ||||
Sequence: AFFHLLTHALFKALLFMCAGAII | ||||||
Transmembrane | 118-141 | Helical | ||||
Sequence: LTCICMNISNLALCGMPFLAGFYS | ||||||
Transmembrane | 153-178 | Helical | ||||
Sequence: FVNIFIFLLFFTSTGLTVCYSFRLCY | ||||||
Transmembrane | 199-223 | Helical | ||||
Sequence: IMLKSMLLMLMFVIFSGSMLMWLIF | ||||||
Transmembrane | 229-251 | Helical | ||||
Sequence: ICLPIGLKMLALFVSIIGAWLGY | ||||||
Transmembrane | 272-291 | Helical | ||||
Sequence: FFFGFMWFMPNISTFSMNYV | ||||||
Transmembrane | 335-354 | Helical | ||||
Sequence: MKIYLVLIILWVIMLFLISL |
Keywords
- Cellular component
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 2-169 | NADH:quinone oxidoreductase/Mrp antiporter membrane subunit | ||||
Sequence: STLVTAGVYLLIRFNMILNENLCLFLLLISSLTMFMAGLGANFEFDLKKIIALSTLSQLGLMMSILSMGNYKLAFFHLLTHALFKALLFMCAGAIIHNLKDTQDIRFMGNLMVHMPLTCICMNISNLALCGMPFLAGFYSKDLILEVVSMDFVNIFIFLLFFTSTGLT | ||||||
Domain | 172-352 | NADH dehydrogenase subunit 5 C-terminal | ||||
Sequence: YSFRLCYYTITGDFNFYSLHSLNDEGWIMLKSMLLMLMFVIFSGSMLMWLIFPTPVMICLPIGLKMLALFVSIIGAWLGYEMAKFSVSWVSNSLKFYNYSFFFGFMWFMPNISTFSMNYVPLMMSFNLFKSFDQGWNEYFGGQGMYKSMKSNSMFMQFLQNNNMKIYLVLIILWVIMLFLI |
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusFragment
- Length355
- Mass (Da)40,830
- Last updated2009-02-10 v1
- Checksum7B0E33D92105115A
Features
Showing features for non-terminal residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Non-terminal residue | 1 | |||||
Sequence: S | ||||||
Non-terminal residue | 355 | |||||
Sequence: I |
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
FJ470257 EMBL· GenBank· DDBJ | ACK57895.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ470260 EMBL· GenBank· DDBJ | ACK57898.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ470261 EMBL· GenBank· DDBJ | ACK57899.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ470268 EMBL· GenBank· DDBJ | ACK57906.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ470279 EMBL· GenBank· DDBJ | ACK57917.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ470285 EMBL· GenBank· DDBJ | ACK57923.1 EMBL· GenBank· DDBJ | Genomic DNA |