B7QDG3 · NNRE_IXOSC

Function

function

Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.

Catalytic activity

Cofactor

K+ (UniProtKB | Rhea| CHEBI:29103 )

Note: Binds 1 potassium ion per subunit.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site102-106(6S)-NADPHX (UniProtKB | ChEBI)
Binding site103K+ (UniProtKB | ChEBI)
Binding site167K+ (UniProtKB | ChEBI)
Binding site171-177(6S)-NADPHX (UniProtKB | ChEBI)
Binding site200(6S)-NADPHX (UniProtKB | ChEBI)
Binding site203K+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Functionmetal ion binding
Molecular FunctionNADHX epimerase activity
Molecular FunctionNADPHX epimerase activity
Molecular Functionnucleotide binding

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    NAD(P)H-hydrate epimerase
  • EC number
  • Alternative names
    • NAD(P)HX epimerase

Gene names

    • ORF names
      ISCW022186

Organism names

Accessions

  • Primary accession
    B7QDG3

Proteomes

Organism-specific databases

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00004163191-275NAD(P)H-hydrate epimerase

Proteomic databases

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain49-258YjeF N-terminal

Sequence similarities

Belongs to the NnrE/AIBP family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    275
  • Mass (Da)
    30,463
  • Last updated
    2009-02-10 v1
  • Checksum
    597FF01E78C49F37
MEKSEKKPMRFSFRRRPKSVSVDRSEAHAADVSIGQYLEKLNYVSQEEAIKIDQELFSEYAYSVDQLMELAGLSVATAVAKSYPRGPMPKGGTVLVCCGPGNNGGDGLVCARHLKLFGYEPSVFYPKQSNKPLFQNLTKQCQEMEVPFLSFLPDSQLVSDSYNLVVDALFGFSFKPPVRPEFNDVMDKLKKVKIPVVSIDIPSGWDVETGGDADSLQPECLVSLTAPKRCSRNFKGRFHWLGGRFVPPALAAKYELNLPPYPGTDCCLLLTPPPS

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
DS913224
EMBL· GenBank· DDBJ
EEC16885.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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