B7Q5K1 · QTRT2_IXOSC

Function

function

Non-catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 1 zinc ion per subunit.

Features

Showing features for binding site.

139450100150200250300350
TypeIDPosition(s)Description
Binding site336Zn2+ (UniProtKB | ChEBI)
Binding site338Zn2+ (UniProtKB | ChEBI)
Binding site341Zn2+ (UniProtKB | ChEBI)
Binding site367Zn2+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functionmetal ion binding
Molecular FunctiontRNA-guanosine(34) queuine transglycosylase activity
Biological ProcesstRNA-guanine transglycosylation

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Queuine tRNA-ribosyltransferase accessory subunit 2
  • Alternative names
    • Queuine tRNA-ribosyltransferase domain-containing protein 1

Gene names

    • ORF names
      ISCW021855

Organism names

Accessions

  • Primary accession
    B7Q5K1

Proteomes

Organism-specific databases

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00003839441-394Queuine tRNA-ribosyltransferase accessory subunit 2

Proteomic databases

Interaction

Subunit

Heterodimer of a catalytic subunit and an accessory subunit.

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Belongs to the queuine tRNA-ribosyltransferase family. QTRT2 subfamily.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    394
  • Mass (Da)
    43,748
  • Last updated
    2009-02-10 v1
  • Checksum
    5B43C9FACCA6E866
MRFSVVETFHGHRGRLGNICGLRIGTGEQCLDTPTCLLYTQAGSAPHLTRDMLHKLGDVENLPALFPLPPITSFVDSVMQFGKGLGSFVALQSHPSFIRIQDPMVTTPSGFNDKAGVSVWDQGGRVHLNPLSFTRMMEAFQPTCYQALCDSDTPQDASRKRLQRAVDRSVSLLDQCLAMKADSSCLQHSAILGSVQGGYNRDFREISAKETAKRDVDGFVIEGFHVNGPQTKSLKFEEVAEILEEVIALLPQDKPRFLHGVLRPEFILKAVLYGIDIFDASLAHAATEAGCALVFNCSSDKDLELMLGRDLLDQELEMDMKNARHREDFVPLLESCACYACTNFTRAYIHHLLNTGEMLGQVLLSLHNIHHFLGFLKSIRKFMVQHGAKELNGN

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
DS861789
EMBL· GenBank· DDBJ
EEC14123.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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