B7PS00 · LIS1_IXOSC

Function

function

Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentaxon cytoplasm
Cellular Componentcentrosome
Cellular Componentcytoplasmic microtubule
Cellular Componentkinetochore
Cellular Componentmicrotubule associated complex
Cellular Componentneuron projection
Cellular Componentneuronal cell body
Cellular Componentnuclear envelope
Molecular Functiondynein complex binding
Molecular Functionmicrotubule plus-end binding
Biological Processbrain morphogenesis
Biological Processcell division
Biological Processestablishment of mitotic spindle orientation
Biological Processgerm cell development
Biological Processmicrotubule organizing center organization
Biological Processmicrotubule sliding
Biological Processnuclear migration
Biological Processretrograde axonal transport
Biological Processvesicle transport along microtubule

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Lissencephaly-1 homolog

Gene names

    • ORF names
      IscW_ISCW007420

Organism names

Accessions

  • Primary accession
    B7PS00

Proteomes

Organism-specific databases

Subcellular Location

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00004050521-411Lissencephaly-1 homolog

Proteomic databases

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for domain, coiled coil, compositional bias, region, repeat.

Type
IDPosition(s)Description
Domain7-39LisH
Coiled coil54-80
Compositional bias77-93Basic and acidic residues
Region77-96Disordered
Repeat104-145WD 1
Repeat146-187WD 2
Repeat188-227WD 3
Repeat230-269WD 4
Repeat272-334WD 5
Repeat337-376WD 6
Repeat379-411WD 7

Domain

Dimerization mediated by the LisH domain may be required to activate dynein.

Sequence similarities

Belongs to the WD repeat LIS1/nudF family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    411
  • Mass (Da)
    46,091
  • Last updated
    2011-02-08 v2
  • Checksum
    66F5205DCC6E48C7
MVLSQRQREELNKAIADYLASNGFMEALESFKKETDMPGDIDKKYAGLLEKKWTSVIRLQKKVMDLEGRLAEAEKEYISGTPSREKRSPTEWIPRPPERSALLGHRAPITRVLFHPVYSVVVSASEDASIKVWDYETGDFERTIKGHTDSVQDIAFDHTGQFLASCSADMTIKLWDFKSYECLRTMHGHDHNVSSVCFLPSGDHVVSCSRDKSIKMWEVATGYCVRTFTGHRDWVRMVRVNSDGSLLASCSNDQTVRVWVVGTKECKLELREHDHVVECVAWAPAHAQLCGAAGDSNRRPGAGGAQGTGPFLVSGSRDKTIKVWDVSTGLALFTLVGHDNWVRGVKFHPGGKYLLSASDDKTLRVWELAHQRCCKTLDAHSHFCTSLDFHRTAPYVVTGSVDQTVKVWECR

Sequence caution

The sequence EEC09372.1 differs from that shown. Reason: Erroneous gene model prediction

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias77-93Basic and acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
DS775781
EMBL· GenBank· DDBJ
EEC09372.1
EMBL· GenBank· DDBJ
Genomic DNA Sequence problems.

Genome annotation databases

Similar Proteins

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