B7PS00 · LIS1_IXOSC
- ProteinLissencephaly-1 homolog
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids411 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | axon cytoplasm | |
Cellular Component | centrosome | |
Cellular Component | cytoplasmic microtubule | |
Cellular Component | kinetochore | |
Cellular Component | microtubule associated complex | |
Cellular Component | neuron projection | |
Cellular Component | neuronal cell body | |
Cellular Component | nuclear envelope | |
Molecular Function | dynein complex binding | |
Molecular Function | microtubule plus-end binding | |
Biological Process | brain morphogenesis | |
Biological Process | cell division | |
Biological Process | establishment of mitotic spindle orientation | |
Biological Process | germ cell development | |
Biological Process | microtubule organizing center organization | |
Biological Process | microtubule sliding | |
Biological Process | nuclear migration | |
Biological Process | retrograde axonal transport | |
Biological Process | vesicle transport along microtubule |
Keywords
- Biological process
Names & Taxonomy
Protein names
- Recommended nameLissencephaly-1 homolog
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Chelicerata > Arachnida > Acari > Parasitiformes > Ixodida > Ixodoidea > Ixodidae > Ixodinae > Ixodes
Accessions
- Primary accessionB7PS00
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Note: Localizes to the plus end of microtubules and to the centrosome.
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000405052 | 1-411 | Lissencephaly-1 homolog | ||
Proteomic databases
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain, coiled coil, compositional bias, region, repeat.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 7-39 | LisH | |||
Coiled coil | 54-80 | ||||
Compositional bias | 77-93 | Basic and acidic residues | |||
Region | 77-96 | Disordered | |||
Repeat | 104-145 | WD 1 | |||
Repeat | 146-187 | WD 2 | |||
Repeat | 188-227 | WD 3 | |||
Repeat | 230-269 | WD 4 | |||
Repeat | 272-334 | WD 5 | |||
Repeat | 337-376 | WD 6 | |||
Repeat | 379-411 | WD 7 | |||
Domain
Dimerization mediated by the LisH domain may be required to activate dynein.
Sequence similarities
Belongs to the WD repeat LIS1/nudF family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length411
- Mass (Da)46,091
- Last updated2011-02-08 v2
- Checksum66F5205DCC6E48C7
Sequence caution
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 77-93 | Basic and acidic residues | |||
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
DS775781 EMBL· GenBank· DDBJ | EEC09372.1 EMBL· GenBank· DDBJ | Genomic DNA | Sequence problems. |