B7LTL5 · GPDA_ESCF3

Function

function

Catalyzes the reduction of the glycolytic intermediate dihydroxyacetone phosphate (DHAP) to sn-glycerol 3-phosphate (G3P), the key precursor for phospholipid synthesis.

Catalytic activity

Pathway

Membrane lipid metabolism; glycerophospholipid metabolism.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site15NADPH (UniProtKB | ChEBI)
Binding site16NADPH (UniProtKB | ChEBI)
Binding site36NADPH (UniProtKB | ChEBI)
Binding site110NADPH (UniProtKB | ChEBI)
Binding site110sn-glycerol 3-phosphate (UniProtKB | ChEBI)
Binding site139sn-glycerol 3-phosphate (UniProtKB | ChEBI)
Binding site141sn-glycerol 3-phosphate (UniProtKB | ChEBI)
Binding site143NADPH (UniProtKB | ChEBI)
Active site195Proton acceptor
Binding site195sn-glycerol 3-phosphate (UniProtKB | ChEBI)
Binding site248sn-glycerol 3-phosphate (UniProtKB | ChEBI)
Binding site258sn-glycerol 3-phosphate (UniProtKB | ChEBI)
Binding site259NADPH (UniProtKB | ChEBI)
Binding site259sn-glycerol 3-phosphate (UniProtKB | ChEBI)
Binding site260sn-glycerol 3-phosphate (UniProtKB | ChEBI)
Binding site283NADPH (UniProtKB | ChEBI)
Binding site285NADPH (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Functionglycerol-3-phosphate dehydrogenase (NADP+) activity
Molecular Functionglycerol-3-phosphate dehydrogenase [NAD(P)+] activity
Molecular FunctionNAD binding
Biological Processcarbohydrate metabolic process
Biological Processglycerol-3-phosphate biosynthetic process
Biological Processglycerol-3-phosphate catabolic process
Biological Processglycerophospholipid biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Glycerol-3-phosphate dehydrogenase [NAD(P)+]
  • EC number
  • Alternative names
    • NAD(P)(+)-dependent glycerol-3-phosphate dehydrogenase
    • NAD(P)H-dependent dihydroxyacetone-phosphate reductase

Gene names

    • Name
      gpsA
    • Ordered locus names
      EFER_3602

Organism names

Accessions

  • Primary accession
    B7LTL5

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_10001901501-339Glycerol-3-phosphate dehydrogenase [NAD(P)+]

Structure

Family & Domains

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    339
  • Mass (Da)
    36,361
  • Last updated
    2009-02-10 v1
  • Checksum
    094DFFB9969ED4BC
MNQRNASMTVIGAGSYGTALAITLARNGHEVVLWGHDPEHIATLKRDRCNAAFLPDVPFPDTLHLESDLATALAASRNILVVVPSHVFGEVLRQIKPLMRPDARLVWATKGLEAETGRLLQDVAREALGDQIPLAVISGPTFAKELAAGLPTAISLASTDQTFADDLQQLLHCGKSFRVYSNPDFIGVQLGGAVKNVIAIGAGMSDGIGFGANARTALITRGLAEMSRLGAALGADPATFMGMAGLGDLVLTCTDNQSRNRRFGMMLGQGMDVQSAQEKIGQVVEGYRNTKEVRELAHRFGVEMPITEEIYQVLYCGKNAREAALTLLGRARKDERSSH

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CU928158
EMBL· GenBank· DDBJ
CAQ91074.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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