B7GRV8 · METE_BIFLS

Function

function

Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation.

Catalytic activity

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 1 zinc ion per subunit.

Pathway

Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-methionine from L-homocysteine (MetE route): step 1/1.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site17-205-methyltetrahydropteroyltri-L-glutamate (UniProtKB | ChEBI)
Binding site1175-methyltetrahydropteroyltri-L-glutamate (UniProtKB | ChEBI)
Binding site441-443L-homocysteine (UniProtKB | ChEBI)
Binding site441-443L-methionine (UniProtKB | ChEBI)
Binding site494L-homocysteine (UniProtKB | ChEBI)
Binding site494L-methionine (UniProtKB | ChEBI)
Binding site525-5265-methyltetrahydropteroyltri-L-glutamate (UniProtKB | ChEBI)
Binding site5715-methyltetrahydropteroyltri-L-glutamate (UniProtKB | ChEBI)
Binding site609L-homocysteine (UniProtKB | ChEBI)
Binding site609L-methionine (UniProtKB | ChEBI)
Binding site6155-methyltetrahydropteroyltri-L-glutamate (UniProtKB | ChEBI)
Binding site652Zn2+ (UniProtKB | ChEBI); catalytic
Binding site654Zn2+ (UniProtKB | ChEBI); catalytic
Binding site676Zn2+ (UniProtKB | ChEBI); catalytic
Active site705Proton donor
Binding site737Zn2+ (UniProtKB | ChEBI); catalytic

GO annotations

AspectTerm
Molecular Function5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity
Molecular Functionzinc ion binding
Biological Processmethionine biosynthetic process
Biological Processmethylation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase
  • EC number
  • Alternative names
    • Cobalamin-independent methionine synthase
    • Methionine synthase, vitamin-B12 independent isozyme

Gene names

    • Name
      metE
    • Ordered locus names
      Blon_1455, BLIJ_1501

Organism names

Accessions

  • Primary accession
    B7GRV8
  • Secondary accessions
    • E8MKK7

Proteomes

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_10001237791-7675-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase

Structure

Family & Domains

Sequence similarities

Belongs to the vitamin-B12 independent methionine synthase family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    767
  • Mass (Da)
    85,444
  • Last updated
    2009-02-10 v1
  • Checksum
    31ADD0BD14AD7192
MSTLTSVSGFPRIGQNRELKKIIEGYWKGANDLAAVKATAAELRAKHWRLQQAAGIDLIASNDFSYYDQMLDTAILLNVIPQRYQRLAFDDQEDTLFAMARGYQGDKGDVTALPMKKWFTTNYHYLVPEVEPSAEIKLNSTKPFDEFNEAKSLGVETKPVFIGPYTFLKLARTPEAAELEIDKGLVNAVAAVYAEVLARFNDLGAAWVQLDEPYLVLDKEPGDVELFKALYTKILPAKGNVKVLLNTYFGHIADVYETVNLFGFDGIGLDLNEGREENLEAVAKYGVAAGTTIFAGVINGRNIWRNNYATSLGLVDALKQVTADVAVSTASSLLHVPFSTEGETGIPAEDLKHFAFAVQKLGELKEIAALTDATEDEKKSSAALAANQALFDGTRVAADPAVAERIGKLSDADYVRQPAREERQSLQREALGLPLLPTTTIGSFPQTKEIRAERAKLRKGEVTKEAYDEFIASQIDAVIRKQEEIGLDVLVHGEFERNDMVEYFGQNLNGFLFTKNAWVQSYGTRCVKPPIVWGDVSRANPITVEWSAYAQSKTDHVMKGMLTGPVTILNWSWPREDITHEEQTKQLALAIRDEVLDLEAAGIKIIQIDEAALREKLPLRKSDWHAKYLDWAIPAFRLVHSAVKPTTQIHTHMCYSEFNDIIRDIDAMDADVISFEASRGDLVVLDAIHDARFETEAGPGVYDIHSPRIPSEKEIEDRIYEILDKIDVKKVWINPDCGLKTRGNDETWPSLEHLVAAAKAVRARLDK

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP001095
EMBL· GenBank· DDBJ
ACJ52538.1
EMBL· GenBank· DDBJ
Genomic DNA
AP010889
EMBL· GenBank· DDBJ
BAJ69084.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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