B7GRV5 · GLNE_BIFLS

Function

function

Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Function[glutamate-ammonia-ligase] adenylyltransferase activity
Molecular Function[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase activity
Molecular FunctionATP binding
Molecular Functionmagnesium ion binding
Biological Processregulation of glutamine family amino acid metabolic process

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme
  • Alternative names
    • ATP:glutamine synthetase adenylyltransferase
    • ATase

Including 2 domains:

  • Recommended name
    Glutamine synthetase adenylyl-L-tyrosine phosphorylase
  • EC number
  • Alternative names
    • Adenylyl removase
      (AR
      ; AT-N
      )
  • Recommended name
    Glutamine synthetase adenylyl transferase
  • EC number
  • Alternative names
    • Adenylyl transferase
      (AT
      ; AT-C
      )

Gene names

    • Name
      glnE
    • Ordered locus names
      Blon_1452, BLIJ_1498

Organism names

Accessions

  • Primary accession
    B7GRV5
  • Secondary accessions
    • E8MKK4

Proteomes

Subcellular Location

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_10001485411-1076Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme

Structure

Family & Domains

Features

Showing features for region, compositional bias.

Type
IDPosition(s)Description
Region1-521Adenylyl removase
Region524-1076Adenylyl transferase
Region1041-1076Disordered
Compositional bias1062-1076Basic and acidic residues

Sequence similarities

Belongs to the GlnE family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,076
  • Mass (Da)
    119,998
  • Last updated
    2009-02-10 v1
  • Checksum
    7283EB111BFC7999
MESSMFKPSSMDLIRAGLQDLDRARALFGQLKADAIADGRCAELLGVLAHACDPDVALGNFVDIVNAMQSSRRDLDRVIPDAGALRRLITVLGASDAMGKFMRFRPELVEAASVGSADSHLFNRAQRRARLLMAVGADPDDQAMPVASKDLAEAATALRAGYRRQLAAIIAQDVMAEDPIRIQPTISSELSDLADAALEGALAIARHETEGNEHVRFTIIGMGKLGAQELNYVSDVDLIYVVEPADKDVDHQTLIRVGTKMGTMLQRVCQSVIMGVAEQPLWQIDGGLRPEGKDGALVRVLSSHKNYYEQWAENWEFQALLKARPVAGDPDLGQAYMDMSRPFVWSASKRKNFVYDCQKMRKRVEDLIPAPLKDREIKLGRGGLRDVEFTVQMLQLVHGRTDESLRTSNTLDSLQRLSEGGYVSRKQAVRMSQDYRFERVMEHRQQIWSLKRTHLFPDLGRASVGGLEKKRDIDVDELNQNQELRRLARAFGLHPEELVDKYDDTRREVRHLHLDIYYRPMLPVNAQMENDQIVLSVEAAQERFESIGFGDPDAAIRHVQALTAGVGRAAKINRIILPAVLQWLGEGQNPDMGLLNWRKLEENFGTESGYLGFLRDSTSAAQRLCHILSNSRFLGDALNKSVESISWLGDDGNLQARTREALDVQTGSALERFGSNINEFATSMRAMRRHEIERIGLSWMSGVISDSDSLKAMTDVYDAIIDASLTWAVRHQIAAFGVETAPAGITVIAMGRYGGREVNFSSDADAILIYRPADDADDGQANAFAKKVVEDLRNILQGPTTLEPKIELDLDLRPEGKNGPLVRSYASCEEYYESWASTWERQALLRARYAAGDAELARDFLINIADPLRYPTAELTEAELQNIRKLKARMEAERLPRGVRRERHLKLGKGGLSDVEWTVQLMQLQHAGDIKDLRVNGTLEALDVLEAKKLISAIDAIQLRKTWTLCTAARNGNYLWSGRANQADILPDDIYSLGGIAVYLGYGAHRGQHFENDLLAVMRKCRDVCQRLFYGQTEGEATAAATATASAATPQPQTAPRPRMHVIAPRLERNRRRAQR

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias1062-1076Basic and acidic residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP001095
EMBL· GenBank· DDBJ
ACJ52535.1
EMBL· GenBank· DDBJ
Genomic DNA
AP010889
EMBL· GenBank· DDBJ
BAJ69081.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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