B7FXE8 · NNRD_PHATC

Function

function

Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ATP, which is converted to ADP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site117(6S)-NADPHX (UniProtKB | ChEBI)
Binding site172-178(6S)-NADPHX (UniProtKB | ChEBI)
Binding site207-211ATP (UniProtKB | ChEBI)
Binding site227-236ATP (UniProtKB | ChEBI)
Binding site237(6S)-NADPHX (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular FunctionATP binding
Molecular FunctionATP-dependent NAD(P)H-hydrate dehydratase activity
Biological Processmetabolite repair
Biological Processnicotinamide nucleotide metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    ATP-dependent (S)-NAD(P)H-hydrate dehydratase
  • EC number
  • Alternative names
    • ATP-dependent NAD(P)HX dehydratase

Gene names

    • ORF names
      PHATRDRAFT_19831

Organism names

Accessions

  • Primary accession
    B7FXE8

Proteomes

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00004161771-310ATP-dependent (S)-NAD(P)H-hydrate dehydratase

Keywords

Proteomic databases

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain8-306YjeF C-terminal

Sequence similarities

Belongs to the NnrD/CARKD family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    310
  • Mass (Da)
    33,682
  • Last updated
    2009-02-10 v1
  • Checksum
    896A7DC729C20344
MKTWNDGKTIAIERCVLPLDASLHKGSSGRVGVLGGSARYTGAPYYAAMASLQAGADLAFVFCAQEATLPIKSYSPELMVAPVYSASDFDPVRLVDDMVNEIGDMLPKLHCLVVGPGLGRCPLVMKAVARVLELARSQQLHLVLDADALYMMSLPVYRSSLKGYDRLVLTPNVVEYQRLFPKSEDNNGESMEDASDEELAAATIVRKGAEDRIIVDQRQVMSCGEEGGLKRSGGIGDVLAGTLGTFTSWHAILLDREAVSTEDLPLSCWTACCAVKRATKRAFDDKRRAMTAPDVLHHLGQALDEMTRED

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CM000609
EMBL· GenBank· DDBJ
EEC49367.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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