B7FXE8 · NNRD_PHATC
- ProteinATP-dependent (S)-NAD(P)H-hydrate dehydratase
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids310 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ATP, which is converted to ADP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
Catalytic activity
- (6S)-NADHX + ATP = ADP + phosphate + NADH + H+
Cofactor
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 117 | (6S)-NADPHX (UniProtKB | ChEBI) | ||||
Sequence: G | ||||||
Binding site | 172-178 | (6S)-NADPHX (UniProtKB | ChEBI) | ||||
Sequence: NVVEYQR | ||||||
Binding site | 207-211 | ATP (UniProtKB | ChEBI) | ||||
Sequence: KGAED | ||||||
Binding site | 227-236 | ATP (UniProtKB | ChEBI) | ||||
Sequence: GGLKRSGGIG | ||||||
Binding site | 237 | (6S)-NADPHX (UniProtKB | ChEBI) | ||||
Sequence: D |
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | ATP binding | |
Molecular Function | ATP-dependent NAD(P)H-hydrate dehydratase activity | |
Biological Process | metabolite repair | |
Biological Process | nicotinamide nucleotide metabolic process |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameATP-dependent (S)-NAD(P)H-hydrate dehydratase
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Sar > Stramenopiles > Ochrophyta > Bacillariophyta > Bacillariophyceae > Bacillariophycidae > Naviculales > Phaeodactylaceae > Phaeodactylum
Accessions
- Primary accessionB7FXE8
Proteomes
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000416177 | 1-310 | ATP-dependent (S)-NAD(P)H-hydrate dehydratase | |||
Sequence: MKTWNDGKTIAIERCVLPLDASLHKGSSGRVGVLGGSARYTGAPYYAAMASLQAGADLAFVFCAQEATLPIKSYSPELMVAPVYSASDFDPVRLVDDMVNEIGDMLPKLHCLVVGPGLGRCPLVMKAVARVLELARSQQLHLVLDADALYMMSLPVYRSSLKGYDRLVLTPNVVEYQRLFPKSEDNNGESMEDASDEELAAATIVRKGAEDRIIVDQRQVMSCGEEGGLKRSGGIGDVLAGTLGTFTSWHAILLDREAVSTEDLPLSCWTACCAVKRATKRAFDDKRRAMTAPDVLHHLGQALDEMTRED |
Keywords
- PTM
Proteomic databases
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 8-306 | YjeF C-terminal | ||||
Sequence: KTIAIERCVLPLDASLHKGSSGRVGVLGGSARYTGAPYYAAMASLQAGADLAFVFCAQEATLPIKSYSPELMVAPVYSASDFDPVRLVDDMVNEIGDMLPKLHCLVVGPGLGRCPLVMKAVARVLELARSQQLHLVLDADALYMMSLPVYRSSLKGYDRLVLTPNVVEYQRLFPKSEDNNGESMEDASDEELAAATIVRKGAEDRIIVDQRQVMSCGEEGGLKRSGGIGDVLAGTLGTFTSWHAILLDREAVSTEDLPLSCWTACCAVKRATKRAFDDKRRAMTAPDVLHHLGQALDEM |
Sequence similarities
Belongs to the NnrD/CARKD family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length310
- Mass (Da)33,682
- Last updated2009-02-10 v1
- Checksum896A7DC729C20344
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CM000609 EMBL· GenBank· DDBJ | EEC49367.1 EMBL· GenBank· DDBJ | Genomic DNA |