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B6ZB00 · B6ZB00_HPV58

Function

function

ATP-dependent DNA helicase required for initiation of viral DNA replication. It forms a complex with the viral E2 protein. The E1-E2 complex binds to the replication origin which contains binding sites for both proteins. During the initial step, a dimer of E1 interacts with a dimer of protein E2 leading to a complex that binds the viral origin of replication with high specificity. Then, a second dimer of E1 displaces the E2 dimer in an ATP-dependent manner to form the E1 tetramer. Following this, two E1 monomers are added to each half of the site, which results in the formation of two E1 trimers on the viral ori. Subsequently, two hexamers will be created. The double hexamer acts as a bi-directional helicase machinery and unwinds the viral DNA and then recruits the host DNA polymerase to start replication.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site470-477ATP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componenthost cell nucleus
Molecular FunctionATP binding
Molecular FunctionDNA binding
Molecular FunctionDNA helicase activity
Molecular Functionhydrolase activity, acting on acid anhydrides
Biological ProcessDNA replication

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Replication protein E1
  • EC number
  • Alternative names
    • ATP-dependent helicase E1

Gene names

    • Name
      E1

Organism names

  • Taxonomic identifier
  • Organism
  • Strains
    • HPV58sc100
    • HPV58sc101
    • HPV58sc165
    • HPV58sc78
    • AS347
  • Taxonomic lineage
    Viruses > Monodnaviria > Shotokuvirae > Cossaviricota > Papovaviricetes > Zurhausenvirales > Papillomaviridae > Firstpapillomavirinae > Alphapapillomavirus > Alphapapillomavirus 9

Accessions

  • Primary accession
    B6ZB00

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for cross-link.

TypeIDPosition(s)Description
Cross-link551Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)

Post-translational modification

Phosphorylated.
Sumoylated.

Keywords

Expression

Keywords

Interaction

Subunit

Can form hexamers. Interacts with E2 protein; this interaction increases E1 DNA binding specificity. Interacts with host DNA polymerase subunit POLA2. Interacts with host single stranded DNA-binding protein RPA1. Interacts with host TOP1; this interaction stimulates the enzymatic activity of TOP1.

Structure

3D structure databases

Family & Domains

Features

Showing features for motif, region, domain.

Type
IDPosition(s)Description
Motif86-88Nuclear localization signal
Region146-177Disordered
Region179-345DNA-binding region
Domain444-594SF3 helicase

Sequence similarities

Belongs to the papillomaviridae E1 protein family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    644
  • Mass (Da)
    72,243
  • Last updated
    2009-01-20 v1
  • MD5 Checksum
    7B9184F4DFB1C85705E7117BDD0B9AF9
MDDPEGTNGVGAGCTGWFEVEAVIERRTGDNISDDEDETADDSGTDLIEFIDDSVQSTTQAEAEAARALFNVQEGVDDINAVCALKRKFAACSESAVEDCVDRAANVCVSWKYKNKECTHRKRKIIELEDSGYGNTEVETEQMAHQVESQNGDADLNDSESSGVGASSDVSSETDVDSCNTVPLQNISNILHNSNTKATLLYKFKEAYGVSFMELVRPFKSDKTSCTDWCITGYGISPSVAESLKVLIKQHSIYTHLQCLTCDRGIILLLLIRFKCSKNRLTVAKLMSNLLSIPETCMIIEPPKLRSQACALYWFRTAMSNISDVQGTTPEWIDRLTVLQHSFNDDIFDLSEMIQWAYDNDITDDSDIAYKYAQLADVNSNAAAFLRSNAQAKIVKDCGVMCRHYKRAEKRGMTMGQWIQSRCEKTNDGGNWRPIVQFLRYQNIEFTAFLVAFKQFLQGVPKKSCMLLCGPANTGKSYFGMSLIHFLKGCIISYVNSKSHFWLQPLSDAKLGMIDDVTAISWTYIDDYMRNALDGNDISIDVKHRALVQLKCPPLIITSNTNAGKDSRWPYLHSRLTVFEFNNPFPFDANGNPVYKINDENWKSFFSRTWCKLGLIEEEDKENDGGNISTFKCSAGQNPRHIRS

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
FJ385261
EMBL· GenBank· DDBJ
ACJ13451.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ385262
EMBL· GenBank· DDBJ
ACJ13459.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ385265
EMBL· GenBank· DDBJ
ACJ13483.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ385268
EMBL· GenBank· DDBJ
ACJ13507.1
EMBL· GenBank· DDBJ
Genomic DNA
HQ537757
EMBL· GenBank· DDBJ
AEI61648.1
EMBL· GenBank· DDBJ
Genomic DNA
HQ537759
EMBL· GenBank· DDBJ
AEI61664.1
EMBL· GenBank· DDBJ
Genomic DNA
HQ537760
EMBL· GenBank· DDBJ
AEI61672.1
EMBL· GenBank· DDBJ
Genomic DNA
KC860270
EMBL· GenBank· DDBJ
AGQ21859.1
EMBL· GenBank· DDBJ
Genomic DNA
KY225918
EMBL· GenBank· DDBJ
ASQ41704.1
EMBL· GenBank· DDBJ
Genomic DNA
KY225919
EMBL· GenBank· DDBJ
ASQ41712.1
EMBL· GenBank· DDBJ
Genomic DNA
KY225936
EMBL· GenBank· DDBJ
ASQ41848.1
EMBL· GenBank· DDBJ
Genomic DNA
KY225937
EMBL· GenBank· DDBJ
ASQ41856.1
EMBL· GenBank· DDBJ
Genomic DNA
KY225939
EMBL· GenBank· DDBJ
ASQ41872.1
EMBL· GenBank· DDBJ
Genomic DNA
KY225941
EMBL· GenBank· DDBJ
ASQ41888.1
EMBL· GenBank· DDBJ
Genomic DNA
KY225944
EMBL· GenBank· DDBJ
ASQ41912.1
EMBL· GenBank· DDBJ
Genomic DNA
KY225945
EMBL· GenBank· DDBJ
ASQ41920.1
EMBL· GenBank· DDBJ
Genomic DNA
KY225946
EMBL· GenBank· DDBJ
ASQ41928.1
EMBL· GenBank· DDBJ
Genomic DNA
KY225947
EMBL· GenBank· DDBJ
ASQ41936.1
EMBL· GenBank· DDBJ
Genomic DNA
KY225948
EMBL· GenBank· DDBJ
ASQ41944.1
EMBL· GenBank· DDBJ
Genomic DNA
KY225950
EMBL· GenBank· DDBJ
ASQ41960.1
EMBL· GenBank· DDBJ
Genomic DNA
KY225951
EMBL· GenBank· DDBJ
ASQ41968.1
EMBL· GenBank· DDBJ
Genomic DNA
KY225952
EMBL· GenBank· DDBJ
ASQ41976.1
EMBL· GenBank· DDBJ
Genomic DNA
KY225953
EMBL· GenBank· DDBJ
ASQ41984.1
EMBL· GenBank· DDBJ
Genomic DNA
KY225954
EMBL· GenBank· DDBJ
ASQ41992.1
EMBL· GenBank· DDBJ
Genomic DNA
KY225955
EMBL· GenBank· DDBJ
ASQ42000.1
EMBL· GenBank· DDBJ
Genomic DNA
AB819279
EMBL· GenBank· DDBJ
BAN63332.1
EMBL· GenBank· DDBJ
Genomic DNA
LC270077
EMBL· GenBank· DDBJ
BBA19984.1
EMBL· GenBank· DDBJ
Genomic DNA
LC270078
EMBL· GenBank· DDBJ
BBA19992.1
EMBL· GenBank· DDBJ
Genomic DNA
LC270081
EMBL· GenBank· DDBJ
BBA20016.1
EMBL· GenBank· DDBJ
Genomic DNA
LC270083
EMBL· GenBank· DDBJ
BBA20032.1
EMBL· GenBank· DDBJ
Genomic DNA
LC270084
EMBL· GenBank· DDBJ
BBA20040.1
EMBL· GenBank· DDBJ
Genomic DNA
LC270085
EMBL· GenBank· DDBJ
BBA20048.1
EMBL· GenBank· DDBJ
Genomic DNA
LC270088
EMBL· GenBank· DDBJ
BBA20072.1
EMBL· GenBank· DDBJ
Genomic DNA
LC270091
EMBL· GenBank· DDBJ
BBA20096.1
EMBL· GenBank· DDBJ
Genomic DNA
LC270096
EMBL· GenBank· DDBJ
BBA20136.1
EMBL· GenBank· DDBJ
Genomic DNA
LC270098
EMBL· GenBank· DDBJ
BBA20152.1
EMBL· GenBank· DDBJ
Genomic DNA
LC270099
EMBL· GenBank· DDBJ
BBA20160.1
EMBL· GenBank· DDBJ
Genomic DNA
LC270101
EMBL· GenBank· DDBJ
BBA20176.1
EMBL· GenBank· DDBJ
Genomic DNA
LC270103
EMBL· GenBank· DDBJ
BBA20192.1
EMBL· GenBank· DDBJ
Genomic DNA
LC270106
EMBL· GenBank· DDBJ
BBA20216.1
EMBL· GenBank· DDBJ
Genomic DNA
LC270110
EMBL· GenBank· DDBJ
BBA20248.1
EMBL· GenBank· DDBJ
Genomic DNA
LC270113
EMBL· GenBank· DDBJ
BBA20272.1
EMBL· GenBank· DDBJ
Genomic DNA
LC270115
EMBL· GenBank· DDBJ
BBA20288.1
EMBL· GenBank· DDBJ
Genomic DNA
LC270117
EMBL· GenBank· DDBJ
BBA20304.1
EMBL· GenBank· DDBJ
Genomic DNA
LC270121
EMBL· GenBank· DDBJ
BBA20336.1
EMBL· GenBank· DDBJ
Genomic DNA
LC270123
EMBL· GenBank· DDBJ
BBA20352.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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