B6S6C6 · B6S6C6_CLYSU

Function

function

Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.

Catalytic activity

Cofactor

heme (UniProtKB | Rhea| CHEBI:30413 )

Pathway

Energy metabolism; oxidative phosphorylation.

GO annotations

AspectTerm
Cellular Componentmitochondrial inner membrane
Molecular Functioncytochrome-c oxidase activity
Molecular Functionheme binding
Molecular Functionmetal ion binding
Biological Processelectron transport coupled proton transport
Biological Processmitochondrial electron transport, cytochrome c to oxygen

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Cytochrome c oxidase subunit 1
  • EC number

Gene names

    • Name
      COI

Encoded on

  • Mitochondrion

Organism names

  • Taxonomic identifier
  • Strains
    • Panama 1 code CLSB1
    • Panama 2 code CLSB2
    • Panama 3 code CLSB3
    • Panama 4 code CLSB4
    • Panama 5 code CLSB5
  • Taxonomic lineage
    Eukaryota > Metazoa > Echinodermata > Eleutherozoa > Echinozoa > Echinoidea > Euechinoidea > Gnathostomata > Clypeasteroida > Clypeasteridae > Clypeaster

Accessions

  • Primary accession
    B6S6C6

Subcellular Location

Membrane
; Multi-pass membrane protein
Mitochondrion inner membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane15-33Helical
Transmembrane40-63Helical
Transmembrane75-98Helical
Transmembrane110-131Helical
Transmembrane151-172Helical
Transmembrane184-203Helical

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-213Cytochrome oxidase subunit I profile

Sequence similarities

Belongs to the heme-copper respiratory oxidase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    213
  • Mass (Da)
    24,102
  • Last updated
    2008-12-16 v1
  • Checksum
    CDF8F36A5B853ECC
ILFQHLFWFFGHPEVYILILPGFGMISHVIAHYSGKREPFGYLGMVYAMIAIGILGFLVWAHHMFTVGMDVDTRAYFTAATMIIAVPTGIKVFSWMATLQGSNLQWETPLLWALGFVFLFTLGGLTGIVLANSSIDVVLHDTYYVVAHFHYVLSMGAVFAIFAGFTHWFPLFSGYSLHPLWSKAHFFIMFIGVNLTFFPQHFLGLAGMPRRYS

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1
Non-terminal residue213

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
EU669844
EMBL· GenBank· DDBJ
ACF95983.1
EMBL· GenBank· DDBJ
Genomic DNA
EU669845
EMBL· GenBank· DDBJ
ACF95984.1
EMBL· GenBank· DDBJ
Genomic DNA
EU669846
EMBL· GenBank· DDBJ
ACF95985.1
EMBL· GenBank· DDBJ
Genomic DNA
EU669847
EMBL· GenBank· DDBJ
ACF95986.1
EMBL· GenBank· DDBJ
Genomic DNA
EU669848
EMBL· GenBank· DDBJ
ACF95987.1
EMBL· GenBank· DDBJ
Genomic DNA
EU669849
EMBL· GenBank· DDBJ
ACF95988.1
EMBL· GenBank· DDBJ
Genomic DNA
EU669850
EMBL· GenBank· DDBJ
ACF95989.1
EMBL· GenBank· DDBJ
Genomic DNA
EU669851
EMBL· GenBank· DDBJ
ACF95990.1
EMBL· GenBank· DDBJ
Genomic DNA
EU669852
EMBL· GenBank· DDBJ
ACF95991.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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